LMO4

LIM domain only 4
File:PBB Protein LMO4 image.jpg PDB rendering based on 1rut.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1rut​, 2dfy​
Identifiers
Symbols	LMO4 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4927
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LMO4 209205 s at tn.png
File:PBB GE LMO4 209204 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

LIM domain only 4, also known as LMO4, is a human gene.

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.

Further reading

• Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. PMID 9736723.CS1 maint: Multiple names: authors list (link)
• Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene". Biochim. Biophys. Acta. 1445 (1): 148–53. PMID 10209267.CS1 maint: Multiple names: authors list (link)
• Tse E, Grutz G, Garner AA; et al. (2000). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping". Mamm. Genome. 10 (11): 1089–94. PMID 10556429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sum EY, Peng B, Yu X; et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. PMID 12153047.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vu D, Marin P, Walzer C; et al. (2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells". Brain Res. Mol. Brain Res. 115 (2): 93–103. PMID 12877980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manetopoulos C, Hansson A, Karlsson J; et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun. 307 (4): 891–9. PMID 12878195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sutherland KD, Visvader JE, Choong DY; et al. (2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. PMID 12925972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction". J. Biol. Chem. 280 (13): 12747–57. doi:10.1074/jbc.M500175200. PMID 15677447.CS1 maint: Multiple names: authors list (link)
• Sun T, Patoine C, Abu-Khalil A; et al. (2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex". Science. 308 (5729): 1794–8. doi:10.1126/science.1110324. PMID 15894532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sum EY, Segara D, Duscio B; et al. (2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659–64. doi:10.1073/pnas.0502990102. PMID 15897450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jeffries CM, Graham SC, Stokes PH; et al. (2007). "Stabilization of a binary protein complex by intein-mediated cyclization". Protein Sci. 15 (11): 2612–8. doi:10.1110/ps.062377006. PMID 17001033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)