MAD2L1

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MAD2 mitotic arrest deficient-like 1 (yeast)
File:PBB Protein MAD2L1 image.jpg
PDB rendering based on 1duj.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols MAD2L1 ; HSMAD2; MAD2
External IDs Template:OMIM5 Template:MGI HomoloGene: 1768
RNA expression pattern
File:PBB GE MAD2L1 203362 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

MAD2 mitotic arrest deficient-like 1 (yeast), also known as MAD2L1, is a human gene.[1]

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Li Y, Benezra R (1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science. 274 (5285): 246–8. PMID 8824189.
  • O'Neill TJ, Zhu Y, Gustafson TA (1997). "Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation". J. Biol. Chem. 272 (15): 10035–40. PMID 9092546.
  • Xu L, Deng HX, Yang Y; et al. (1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet. Cell Genet. 78 (1): 63–4. PMID 9345911.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Jin DY, Spencer F, Jeang KT (1998). "Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1". Cell. 93 (1): 81–91. PMID 9546394.
  • Krishnan R, Goodman B, Jin DY; et al. (1998). "Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27". Genomics. 49 (3): 475–8. doi:10.1006/geno.1998.5233. PMID 9615237.
  • Kallio M, Weinstein J, Daum JR; et al. (1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. 141 (6): 1393–406. PMID 9628895.
  • Fang G, Yu H, Kirschner MW (1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes Dev. 12 (12): 1871–83. PMID 9637688.
  • Wassmann K, Benezra R (1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11193–8. PMID 9736712.
  • Liu YC, Pan J, Zhang C; et al. (1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4313–8. PMID 10200259.
  • Cahill DP, da Costa LT, Carson-Walter EB; et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
  • Nelson KK, Schlöndorff J, Blobel CP (2000). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 Pt 3: 673–80. PMID 10527948.
  • Murakumo Y, Roth T, Ishii H; et al. (2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. PMID 10660610.
  • Luo X, Fang G, Coldiron M; et al. (2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. 7 (3): 224–9. doi:10.1038/73338. PMID 10700282.
  • Poelzl G, Kasai Y, Mochizuki N; et al. (2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2836–9. doi:10.1073/pnas.050580997. PMID 10706629.
  • Steuerwald N, Cohen J, Herrera RJ; et al. (2001). "Association between spindle assembly checkpoint expression and maternal age in human oocytes". Mol. Hum. Reprod. 7 (1): 49–55. PMID 11134360.
  • Campbell MS, Chan GK, Yen TJ (2001). "Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase". J. Cell. Sci. 114 (Pt 5): 953–63. PMID 11181178.
  • Zhang Y, Lees E (2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15): 5190–9. doi:10.1128/MCB.21.15.5190-5199.2001. PMID 11438673.
  • Sudakin V, Chan GK, Yen TJ (2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5): 925–36. doi:10.1083/jcb.200102093. PMID 11535616.

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