MAGI1

Membrane associated guanylate kinase, WW and PDZ domain containing 1
File:PBB Protein MAGI1 image.jpg PDB rendering based on 2i04.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2i04​
Identifiers
Symbols	MAGI1 ; BAP1; AIP3; BAIAP1; MAGI-1; TNRC19; WWP3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31257
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAGI1 206144 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Membrane associated guanylate kinase, WW and PDZ domain containing 1, also known as MAGI1, is a human gene.

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Pirozzi G, McConnell SJ, Uveges AJ; et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Margolis RL, Abraham MR, Gatchell SB; et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114–22. PMID 9225980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dobrosotskaya I, Guy RK, James GL (1998). "MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains". J. Biol. Chem. 272 (50): 31589–97. PMID 9395497.CS1 maint: Multiple names: authors list (link)
• Wood JD, Yuan J, Margolis RL; et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiratsuchi T, Futamura M, Oda K; et al. (1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dobrosotskaya IY, James GL (2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures". Biochem. Biophys. Res. Commun. 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. PMID 10772923.
• Patrie KM, Drescher AJ, Goyal M; et al. (2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". J. Am. Soc. Nephrol. 12 (4): 667–77. PMID 11274227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dobrosotskaya IY (2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1". Biochem. Biophys. Res. Commun. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
• Laura RP, Ross S, Koeppen H, Lasky LA (2002). "MAGI-1: a widely expressed, alternatively spliced tight junction protein". Exp. Cell Res. 275 (2): 155–70. doi:10.1006/excr.2002.5475. PMID 11969287.CS1 maint: Multiple names: authors list (link)
• Patrie KM, Drescher AJ, Welihinda A; et al. (2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohno H, Hirabayashi S, Kansaku A; et al. (2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hruska-Hageman AM, Benson CJ, Leonard AS; et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wright GJ, Leslie JD, Ariza-McNaughton L, Lewis J (2005). "Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development". Development. 131 (22): 5659–69. doi:10.1242/dev.01417. PMID 15509766.CS1 maint: Multiple names: authors list (link)
• Benzinger A, Muster N, Koch HB; et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizuhara E, Nakatani T, Minaki Y; et al. (2005). "MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface". J. Biol. Chem. 280 (28): 26499–507. doi:10.1074/jbc.M500375200. PMID 15908431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
• Bratt A, Birot O, Sinha I; et al. (2005). "Angiomotin regulates endothelial cell-cell junctions and cell motility". J. Biol. Chem. 280 (41): 34859–69. doi:10.1074/jbc.M503915200. PMID 16043488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai A, Fukuhara S, Yamagishi A; et al. (2006). "MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion". Mol. Biol. Cell. 17 (2): 966–76. doi:10.1091/mbc.E05-07-0647. PMID 16339077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)