MAL (gene)

Mal, T-cell differentiation protein
Identifiers
Symbols	MAL ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7827
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAL 204777 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mal, T-cell differentiation protein, also known as MAL, is a human gene.

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.

Further reading

• Frank M (2000). "MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond". Prog. Neurobiol. 60 (6): 531–44. PMID 10739088.
• Alonso MA, Barton DE, Francke U (1988). "Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen----q13". Immunogenetics. 27 (2): 91–5. PMID 3257199.CS1 maint: Multiple names: authors list (link)
• Alonso MA, Weissman SM (1987). "cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation". Proc. Natl. Acad. Sci. U.S.A. 84 (7): 1997–2001. PMID 3494249.
• Rancaño C, Rubio T, Alonso MA (1994). "Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene". Genomics. 21 (2): 447–50. doi:10.1006/geno.1994.1294. PMID 8088843.CS1 maint: Multiple names: authors list (link)
• Rancaño C, Rubio T, Correas I, Alonso MA (1994). "Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein". J. Biol. Chem. 269 (11): 8159–64. PMID 8132541.CS1 maint: Multiple names: authors list (link)
• Millán J, Puertollano R, Fan L; et al. (1997). "The MAL proteolipid is a component of the detergent-insoluble membrane subdomains of human T-lymphocytes". Biochem. J. 321 ( Pt 1): 247–52. PMID 9003426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Millán J, Puertollano R, Fan L, Alonso MA (1997). "Caveolin and MAL, two protein components of internal detergent-insoluble membranes, are in distinct lipid microenvironments in MDCK cells". Biochem. Biophys. Res. Commun. 233 (3): 707–12. doi:10.1006/bbrc.1997.6530. PMID 9168919.CS1 maint: Multiple names: authors list (link)
• Martín-Belmonte F, Kremer L, Albar JP; et al. (1998). "Expression of the MAL gene in the thyroid: the MAL proteolipid, a component of glycolipid-enriched membranes, is apically distributed in thyroid follicles". Endocrinology. 139 (4): 2077–84. PMID 9528996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Köhler C, Håkansson A, Svanborg C; et al. (1999). "Protease activation in apoptosis induced by MAL". Exp. Cell Res. 249 (2): 260–8. doi:10.1006/excr.1999.4472. PMID 10366425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frank M, Schaeren-Wiemers N, Schneider R, Schwab ME (1999). "Developmental expression pattern of the myelin proteolipid MAL indicates different functions of MAL for immature Schwann cells and in a late step of CNS myelinogenesis". J. Neurochem. 73 (2): 587–97. PMID 10428054.CS1 maint: Multiple names: authors list (link)
• Puertollano R, Alonso MA (1999). "MAL, an integral element of the apical sorting machinery, is an itinerant protein that cycles between the trans-Golgi network and the plasma membrane". Mol. Biol. Cell. 10 (10): 3435–47. PMID 10512878.
• Erne B, Sansano S, Frank M, Schaeren-Wiemers N (2002). "Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers". J. Neurochem. 82 (3): 550–62. PMID 12153479.CS1 maint: Multiple names: authors list (link)
• Copie-Bergman C, Plonquet A, Alonso MA; et al. (2003). "MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas". Mod. Pathol. 15 (11): 1172–80. doi:10.1097/01.MP.0000032534.81894.B3. PMID 12429796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kazemi-Noureini S, Colonna-Romano S, Ziaee AA; et al. (2004). "Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression". World J. Gastroenterol. 10 (12): 1716–21. PMID 15188492.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Llorente A, de Marco MC, Alonso MA (2005). "Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line". J. Cell. Sci. 117 (Pt 22): 5343–51. doi:10.1242/jcs.01420. PMID 15466889.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dukhovny A, Goldstein Magal L, Hirschberg K (2006). "The MAL proteolipid restricts detergent-mediated membrane pore expansion and percolation". Mol. Membr. Biol. 23 (3): 245–57. doi:10.1080/09687860600601445. PMID 16785208.CS1 maint: Multiple names: authors list (link)
• Mimori K, Nishida K, Nakamura Y; et al. (2007). "Loss of MAL expression in precancerous lesions of the esophagus". Ann. Surg. Oncol. 14 (5): 1670–7. doi:10.1245/s10434-006-9064-2. PMID 17151798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)