MAML1

Mastermind-like 1 (Drosophila)
File:PBB Protein MAML1 image.jpg PDB rendering based on 2f8x.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2f8x​
Identifiers
Symbols	MAML1 ; KIAA0200; Mam-1; Mam1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8845
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mastermind-like 1 (Drosophila), also known as MAML1, is a human gene.

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Further reading

• Alves-Guerra MC, Ronchini C, Capobianco AJ (2007). "Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival". Cancer Res. 67 (18): 8690–8. doi:10.1158/0008-5472.CAN-07-1720. PMID 17875709.CS1 maint: Multiple names: authors list (link)
• Zhao Y, Katzman RB, Delmolino LM; et al. (2007). "The notch regulator MAML1 interacts with p53 and functions as a coactivator". J. Biol. Chem. 282 (16): 11969–81. doi:10.1074/jbc.M608974200. PMID 17317671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nam Y, Sliz P, Song L; et al. (2006). "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes". Cell. 124 (5): 973–83. doi:10.1016/j.cell.2005.12.037. PMID 16530044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover". Mol. Cell. 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.CS1 maint: Multiple names: authors list (link)
• Nam Y, Weng AP, Aster JC, Blacklow SC (2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. PMID 12391150.CS1 maint: Multiple names: authors list (link)
• Lin SE, Oyama T, Nagase T; et al. (2003). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". J. Biol. Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fryer CJ, Lamar E, Turbachova I; et al. (2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMID 12050117.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu G, Lyapina S, Das I; et al. (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation". Mol. Cell. Biol. 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. PMID 11585921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitagawa M, Oyama T, Kawashima T; et al. (2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol. Cell. Biol. 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMID 11390662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu L, Aster JC, Blacklow SC; et al. (2001). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat. Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Seki N, Ishikawa K; et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)". DNA Res. 3 (1): 43–53. PMID 8724853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Seki N, Ishikawa K; et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. PMID 8724849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)