MAP1B

Microtubule-associated protein 1B
Identifiers
Symbols	MAP1B ; DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38111
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP1B 214577 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Microtubule-associated protein 1B, also known as MAP1B, is a human gene.

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.

Further reading

• Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain". Neuron. 7 (1): 129–39. PMID 1712602.CS1 maint: Multiple names: authors list (link)
• Lien LL, Boyce FM, Kleyn P; et al. (1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. PMID 1881920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. PMID 2470876.CS1 maint: Multiple names: authors list (link)
• Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis". Cell Biol. Int. 18 (5): 309–14. PMID 7519512.CS1 maint: Multiple names: authors list (link)
• Lien LL, Feener CA, Fischbach N, Kunkel LM (1995). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.CS1 maint: Multiple names: authors list (link)
• Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions". Brain Dev. 20 (1): 22–6. PMID 9533556.
• Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium". J. Cell. Sci. 111 ( Pt 10): 1351–61. PMID 9570753.CS1 maint: Multiple names: authors list (link)
• Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain". J. Cell Biol. 143 (3): 695–707. PMID 9813091.CS1 maint: Multiple names: authors list (link)
• Hanley JG, Koulen P, Bedford F; et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jensen PH, Islam K, Kenney J; et al. (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200. PMID 10764738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein". J. Neurochem. 75 (2): 553–62. PMID 10899930.CS1 maint: Multiple names: authors list (link)
• Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. PMID 11002287.CS1 maint: Multiple names: authors list (link)
• Billups D, Hanley JG, Orme M; et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. PMID 11102469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Franzen R, Tanner SL, Dashiell SM; et al. (2002). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein". J. Cell Biol. 155 (6): 893–8. doi:10.1083/jcb.200108137. PMID 11733546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ding J, Liu JJ, Kowal AS; et al. (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin". J. Cell Biol. 158 (3): 427–33. doi:10.1083/jcb.200202055. PMID 12147674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2004). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region". Biomol. Eng. 20 (3): 91–6. PMID 12684070.CS1 maint: Multiple names: authors list (link)
• Chang L, Jones Y, Ellisman MH; et al. (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins". Dev. Cell. 4 (4): 521–33. PMID 12689591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Opal P, Garcia JJ, Propst F; et al. (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)