MAP3K1

Mitogen-activated protein kinase kinase kinase 1
Identifiers
Symbols	MAP3K1 ; MAPKKK1; MEKK; MEKK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8056
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP3K1 214786 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitogen-activated protein kinase kinase kinase 1, also known as MAP3K1, is a human gene.

MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM]

Further reading

• Vinik BS, Kay ES, Fiedorek FT (1996). "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5". Mamm. Genome. 6 (11): 782–3. PMID 8597633.CS1 maint: Multiple names: authors list (link)
• Lee FS, Hagler J, Chen ZJ, Maniatis T (1997). "Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway". Cell. 88 (2): 213–22. PMID 9008162.CS1 maint: Multiple names: authors list (link)
• Siow YL, Kalmar GB, Sanghera JS; et al. (1997). "Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C.". J. Biol. Chem. 272 (12): 7586–94. PMID 9065412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su YC, Han J, Xu S; et al. (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain". EMBO J. 16 (6): 1279–90. doi:10.1093/emboj/16.6.1279. PMID 9135144.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu Z, Wu J, Jacinto E, Karin M (1997). "Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase". Mol. Cell. Biol. 17 (12): 7407–16. PMID 9372971.CS1 maint: Multiple names: authors list (link)
• Xu S, Cobb MH (1998). "MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases". J. Biol. Chem. 272 (51): 32056–60. PMID 9405400.
• Fanger GR, Widmann C, Porter AC; et al. (1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. 273 (6): 3476–83. PMID 9452471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirai S, Noda K, Moriguchi T; et al. (1998). "Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2". J. Biol. Chem. 273 (13): 7406–12. PMID 9516438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saltzman A, Searfoss G, Marcireau C; et al. (1998). "hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity". FEBS Lett. 425 (3): 431–5. PMID 9563508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guan Z, Buckman SY, Pentland AP; et al. (1998). "Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway". J. Biol. Chem. 273 (21): 12901–8. PMID 9582321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee FS, Peters RT, Dang LC, Maniatis T (1998). "MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. PMID 9689078.CS1 maint: Multiple names: authors list (link)
• Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". J. Biol. Chem. 273 (35): 22681–92. PMID 9712898.CS1 maint: Multiple names: authors list (link)
• Pomérance M, Multon MC, Parker F; et al. (1998). "Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor". J. Biol. Chem. 273 (38): 24301–4. PMID 9733714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xia Y, Wu Z, Su B; et al. (1998). "JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension". Genes Dev. 12 (21): 3369–81. PMID 9808624.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nemoto S, DiDonato JA, Lin A (1998). "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase". Mol. Cell. Biol. 18 (12): 7336–43. PMID 9819420.CS1 maint: Multiple names: authors list (link)
• Yujiri T, Sather S, Fanger GR, Johnson GL (1998). "Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption". Science. 282 (5395): 1911–4. PMID 9836645.CS1 maint: Multiple names: authors list (link)
• Baud V, Liu ZG, Bennett B; et al. (1999). "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain". Genes Dev. 13 (10): 1297–308. PMID 10346818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kopp E, Medzhitov R, Carothers J; et al. (1999). "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway". Genes Dev. 13 (16): 2059–71. PMID 10465784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito M, Yoshioka K, Akechi M; et al. (1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. PMID 10523642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minamino T, Yujiri T, Papst PJ; et al. (2000). "MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15127–32. PMID 10611349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)