MAP4K4
| Mitogen-activated protein kinase kinase kinase kinase 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | MAP4K4 ; NIK; FLH21957; FLJ10410; FLJ20373; FLJ90111; HGK; KIAA0687 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7442 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE MAP4K4 206571 s at tn.png | |||||||||||
| File:PBB GE MAP4K4 218181 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Mitogen-activated protein kinase kinase kinase kinase 4, also known as MAP4K4, is a human gene.[1]
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]
References
Further reading
- Su YC, Han J, Xu S; et al. (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain". EMBO J. 16 (6): 1279–90. doi:10.1093/emboj/16.6.1279. PMID 9135144.
- Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. PMID 9734811.
- Yao Z, Zhou G, Wang XS; et al. (1999). "A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway". J. Biol. Chem. 274 (4): 2118–25. PMID 9890973.
- Becker E, Huynh-Do U, Holland S; et al. (2000). "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation". Mol. Cell. Biol. 20 (5): 1537–45. PMID 10669731.
- Zhao ZS, Manser E, Lim L (2000). "Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation". Mol. Cell. Biol. 20 (11): 3906–17. PMID 10805734.
- Hofer-Warbinek R, Schmid JA, Stehlik C; et al. (2000). "Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1". J. Biol. Chem. 275 (29): 22064–8. doi:10.1074/jbc.M910346199. PMID 10807933.
- Chaudhary PM, Eby MT, Jasmin A; et al. (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
- Yan W, Nehrke K, Choi J, Barber DL (2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor". J. Biol. Chem. 276 (33): 31349–56. doi:10.1074/jbc.M102679200. PMID 11369779.
- Poinat P, De Arcangelis A, Sookhareea S; et al. (2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans". Curr. Biol. 12 (8): 622–31. PMID 11967148.
- Fong A, Zhang M, Neely J, Sun SC (2002). "S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100". J. Biol. Chem. 277 (43): 40697–702. doi:10.1074/jbc.M205330200. PMID 12185077.
- Luan Z, Zhang Y, Liu A; et al. (2002). "A novel GTP-binding protein hGBP3 interacts with NIK/HGK". FEBS Lett. 530 (1–3): 233–8. PMID 12387898.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Wright JH, Wang X, Manning G; et al. (2003). "The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion". Mol. Cell. Biol. 23 (6): 2068–82. PMID 12612079.
- Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Machida N, Umikawa M, Takei K; et al. (2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". J. Biol. Chem. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Collins CS, Hong J, Sapinoso L; et al. (2006). "A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase". Proc. Natl. Acad. Sci. U.S.A. 103 (10): 3775–80. doi:10.1073/pnas.0600040103. PMID 16537454.
- Wissing J, Jänsch L, Nimtz M; et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |