MAPK6

Mitogen-activated protein kinase 6
File:PBB Protein MAPK6 image.jpg PDB rendering based on 2i6l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2i6l​
Identifiers
Symbols	MAPK6 ; ERK3; DKFZp686F03189; HsT17250; PRKM6; p97MAPK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55683
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAPK6 207121 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitogen-activated protein kinase 6, also known as MAPK6, is a human gene.

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.

Further reading

• Boulton TG, Nye SH, Robbins DJ; et al. (1991). "ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF". Cell. 65 (4): 663–75. PMID 2032290.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMID 7969157.CS1 maint: Multiple names: authors list (link)
• Cheng M, Boulton TG, Cobb MH (1996). "ERK3 is a constitutively nuclear protein kinase". J. Biol. Chem. 271 (15): 8951–8. PMID 8621539.CS1 maint: Multiple names: authors list (link)
• Sauma S, Friedman E (1996). "Increased expression of protein kinase C beta activates ERK3". J. Biol. Chem. 271 (19): 11422–6. PMID 8626698.
• Meloche S, Beatty BG, Pellerin J (1996). "Primary structure, expression and chromosomal locus of a human homolog of rat ERK3". Oncogene. 13 (7): 1575–9. PMID 8875998.CS1 maint: Multiple names: authors list (link)
• Zimmermann J, Lamerant N, Grossenbacher R, Furst P (2001). "Proteasome- and p38-dependent regulation of ERK3 expression". J. Biol. Chem. 276 (14): 10759–66. doi:10.1074/jbc.M008567200. PMID 11148204.CS1 maint: Multiple names: authors list (link)
• Robinson MJ, Xu Be BE, Stippec S, Cobb MH (2002). "Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo". J. Biol. Chem. 277 (7): 5094–100. doi:10.1074/jbc.M110935200. PMID 11741894.CS1 maint: Multiple names: authors list (link)
• Kinet S, Bernard F, Mongellaz C; et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coulombe P, Rodier G, Pelletier S; et al. (2003). "Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation". Mol. Cell. Biol. 23 (13): 4542–58. PMID 12808096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Julien C, Coulombe P, Meloche S (2004). "Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression". J. Biol. Chem. 278 (43): 42615–24. doi:10.1074/jbc.M302724200. PMID 12915405.CS1 maint: Multiple names: authors list (link)
• Rai R, Mahale A, Saranath D (2004). "Molecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma". Oral Oncol. 40 (7): 705–12. doi:10.1016/j.oraloncology.2004.01.010. PMID 15172640.CS1 maint: Multiple names: authors list (link)
• Coulombe P, Rodier G, Bonneil E; et al. (2004). "N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome". Mol. Cell. Biol. 24 (14): 6140–50. doi:10.1128/MCB.24.14.6140-6150.2004. PMID 15226418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoeflich KP, Eby MT, Forrest WF; et al. (2006). "Regulation of ERK3/MAPK6 expression by BRAF". Int. J. Oncol. 29 (4): 839–49. PMID 16964379.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)