MCM7

MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Identifiers
Symbols	MCM7 ; MCM2; CDABP0042; CDC47; P1.1-MCM3; P1CDC47; P85MCM; PNAS-146
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4323
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MCM7 208795 s at tn.png
File:PBB GE MCM7 210983 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MCM7 minichromosome maintenance deficient 7 (S. cerevisiae), also known as MCM7, is a human gene.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

References

• Todorov IT, Lavigne J, Sakr F; et al. (1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem. Biophys. Res. Commun. 177 (1): 395–400. PMID 1710453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Musahl C, Schulte D, Burkhart R, Knippers R (1995). "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins". Eur. J. Biochem. 230 (3): 1096–101. PMID 7601140.CS1 maint: Multiple names: authors list (link)
• Nakatsuru S, Sudo K, Nakamura Y (1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet. Cell Genet. 68 (3–4): 226–30. PMID 7842741.CS1 maint: Multiple names: authors list (link)
• Mincheva A, Todorov I, Werner D; et al. (1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet. Cell Genet. 65 (4): 276–7. PMID 8258304.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu B, Burkhart R, Schulte D; et al. (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins". Nucleic Acids Res. 21 (23): 5289–93. PMID 8265339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1996). "hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase". J. Biol. Chem. 271 (8): 4349–54. PMID 8626784.CS1 maint: Multiple names: authors list (link)
• Schulte D, Richter A, Burkhart R; et al. (1996). "Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins". Eur. J. Biochem. 235 (1–2): 144–51. PMID 8631321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kiyono T, Fujita M, Hayashi Y, Ishibashi M (1996). "Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family". Biochim. Biophys. Acta. 1307 (1): 31–4. PMID 8652665.CS1 maint: Multiple names: authors list (link)
• Ishimi Y, Ichinose S, Omori A; et al. (1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. PMID 8798650.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. PMID 9099751.CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hiraiwa A, Fujita M, Nagasaka T; et al. (1997). "Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth". Int. J. Cancer. 74 (2): 180–4. PMID 9133452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishimi Y (1997). "A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex". J. Biol. Chem. 272 (39): 24508–13. PMID 9305914.
• Sterner JM, Dew-Knight S, Musahl C; et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. 18 (5): 2748–57. PMID 9566894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki S, Adachi A, Hiraiwa A; et al. (1998). "Cloning and characterization of human MCM7 promoter". Gene. 216 (1): 85–91. PMID 9714754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kühne C, Banks L (1999). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. 273 (51): 34302–9. PMID 9852095.
• Fujita M, Yamada C, Goto H; et al. (1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. PMID 10464337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Freeman A, Morris LS, Mills AD; et al. (1999). "Minichromosome maintenance proteins as biological markers of dysplasia and malignancy". Clin. Cancer Res. 5 (8): 2121–32. PMID 10473096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kukimoto I, Igaki H, Kanda T (1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. PMID 10518787.CS1 maint: Multiple names: authors list (link)