MED1

Mediator complex subunit 1
Identifiers
Symbols	MED1 ; PPARBP; PBP; CRSP1; CRSP200; DRIP205; DRIP230; MGC71488; PPARGBP; RB18A; TRAP220; TRIP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21002
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PPARBP 203497 at tn.png
File:PBB GE PPARBP 203496 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mediator complex subunit 1, also known as MED1, is a human gene.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

Further reading

• Lee JW, Choi HS, Gyuris J; et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol. Endocrinol. 9 (2): 243–54. PMID 7776974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. PMID 8710870.CS1 maint: Multiple names: authors list (link)
• Zhu Y, Qi C, Jain S; et al. (1997). "Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor". J. Biol. Chem. 272 (41): 25500–6. PMID 9325263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drané P, Barel M, Balbo M, Frade R (1998). "Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53". Oncogene. 15 (25): 3013–24. doi:10.1038/sj.onc.1201492. PMID 9444950.CS1 maint: Multiple names: authors list (link)
• Yuan CX, Ito M, Fondell JD; et al. (1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7939–44. PMID 9653119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.CS1 maint: Multiple names: authors list (link)
• Gu W, Malik S, Ito M; et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. PMID 10024883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito M, Yuan CX, Malik S; et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. PMID 10198638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rachez C, Lemon BD, Suldan Z; et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Näär AM, Beaurang PA, Zhou S; et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Atkins GB, Hu X, Guenther MG; et al. (1999). "Coactivators for the orphan nuclear receptor RORalpha". Mol. Endocrinol. 13 (9): 1550–7. PMID 10478845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu Y, Qi C, Jain S; et al. (1999). "Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10848–53. PMID 10485914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rachez C, Gamble M, Chang CP; et al. (2000). "The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes". Mol. Cell. Biol. 20 (8): 2718–26. PMID 10733574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frade R, Balbo M, Barel M (2001). "RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity". Cancer Res. 60 (23): 6585–9. PMID 11118038.CS1 maint: Multiple names: authors list (link)
• Zilliacus J, Holter E, Wakui H; et al. (2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. PMID 11266503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crawford SE, Qi C, Misra P; et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frade R, Balbo M, Barel M (2002). "RB18A regulates p53-dependent apoptosis". Oncogene. 21 (6): 861–6. doi:10.1038/sj.onc.1205177. PMID 11840331.CS1 maint: Multiple names: authors list (link)
• Kang YK, Guermah M, Yuan CX, Roeder RG (2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMID 11867769.CS1 maint: Multiple names: authors list (link)
• Misra P, Qi C, Yu S; et al. (2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ge K, Guermah M, Yuan CX; et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)