MSH5
| MutS homolog 5 (E. coli) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | MSH5 ; DKFZp434C1615; G7; MGC2939; MutSH5; NG23 | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8415 | ||||||||
| |||||||||
| RNA expression pattern | |||||||||
| File:PBB GE MSH5 210410 s at tn.png | |||||||||
| File:PBB GE MSH5 221406 s at tn.png | |||||||||
| File:PBB GE MSH5 212913 at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
MutS homolog 5 (E. coli), also known as MSH5, is a human gene.[1]
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing-over. This protein forms heterooligomers with another member of this family, mutS homolog 4. Alternative splicing results in four transcript variants encoding three different isoforms.[1]
References
Further reading
- Her C, Zhao N, Wu X, Tompkins JD (2007). "MutS homologues hMSH4 and hMSH5: diverse functional implications in humans". Front. Biosci. 12: 905–11. PMID 17127347.
- Sargent CA, Dunham I, Campbell RD (1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region". EMBO J. 8 (8): 2305–12. PMID 2477242.
- Albertella MR, Jones H, Thomson W; et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)". Genomics. 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
- Her C, Doggett NA (1999). "Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene". Genomics. 52 (1): 50–61. doi:10.1006/geno.1998.5374. PMID 9740671.
- Winand NJ, Panzer JA, Kolodner RD (1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene". Genomics. 53 (1): 69–80. doi:10.1006/geno.1998.5447. PMID 9787078.
- Edelmann W, Cohen PE, Kneitz B; et al. (1999). "Mammalian MutS homologue 5 is required for chromosome pairing in meiosis". Nat. Genet. 21 (1): 123–7. doi:10.1038/5075. PMID 9916805.
- Bocker T, Barusevicius A, Snowden T; et al. (1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis". Cancer Res. 59 (4): 816–22. PMID 10029069.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B; et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
- Snowden T, Acharya S, Butz C; et al. (2004). "hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes". Mol. Cell. 15 (3): 437–51. doi:10.1016/j.molcel.2004.06.040. PMID 15304223.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Yi W, Wu X, Lee TH; et al. (2005). "Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction". Biochem. Biophys. Res. Commun. 332 (2): 524–32. doi:10.1016/j.bbrc.2005.04.154. PMID 15907804.
- Lee TH, Yi W, Griswold MD; et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment". DNA Repair (Amst.). 5 (1): 32–42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Sekine H, Ferreira RC, Pan-Hammarström Q; et al. (2007). "Role for Msh5 in the regulation of Ig class switch recombination". Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7193–8. doi:10.1073/pnas.0700815104. PMID 17409188.
- Szafranski K, Schindler S, Taudien S; et al. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |