MSI1

Musashi homolog 1 (Drosophila)
File:PBB Protein MSI1 image.jpg PDB rendering based on 1uaw.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1uaw​, 2mss​, 2mst​
Identifiers
Symbols	MSI1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55657
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE MSI1 206333 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Musashi homolog 1 (Drosophila), also known as MSI1, is a human gene.

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.

Further reading

• Okano H, Imai T, Okabe M (2002). "Musashi: a translational regulator of cell fate". J. Cell. Sci. 115 (Pt 7): 1355–9. PMID 11896183.CS1 maint: Multiple names: authors list (link)
• Good P, Yoda A, Sakakibara S; et al. (1998). "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells". Genomics. 52 (3): 382–4. PMID 9790759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toda M, Iizuka Y, Yu W; et al. (2001). "Expression of the neural RNA-binding protein Musashi1 in human gliomas". Glia. 34 (1): 1–7. PMID 11284014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imai T, Tokunaga A, Yoshida T; et al. (2001). "The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA". Mol. Cell. Biol. 21 (12): 3888–900. doi:10.1128/MCB.21.12.3888-3900.2001. PMID 11359897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakakibara S, Nakamura Y, Satoh H, Okano H (2001). "Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS". J. Neurosci. 21 (20): 8091–107. PMID 11588182.CS1 maint: Multiple names: authors list (link)
• Kanemura Y, Mori K, Sakakibara S; et al. (2002). "Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity". Differentiation. 68 (2–3): 141–52. PMID 11686236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanemura Y, Sakakibara S, Okano H (2002). "Identification of Musashi1-positive cells in human normal and neoplastic neuroepithelial tissues by immunohistochemical methods". Methods Mol. Biol. 198: 273–81. doi:10.1385/1-59259-186-8:273. PMID 11951628.CS1 maint: Multiple names: authors list (link)
• Shu HJ, Saito T, Watanabe H; et al. (2002). "Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines". Biochem. Biophys. Res. Commun. 293 (1): 150–4. doi:10.1016/S0006-291X(02)00175-4. PMID 12054577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyanoiri Y, Kobayashi H, Imai T; et al. (2003). "Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics". J. Biol. Chem. 278 (42): 41309–15. doi:10.1074/jbc.M306210200. PMID 12907678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishimura S, Wakabayashi N, Toyoda K; et al. (2003). "Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium". Dig. Dis. Sci. 48 (8): 1523–9. PMID 12924647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lovell MA, Markesbery WR (2005). "Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease". J. Neuropathol. Exp. Neurol. 64 (8): 675–80. PMID 16106215.
• Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM (2006). "The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1". Mol. Cell. Neurosci. 31 (1): 85–96. doi:10.1016/j.mcn.2005.09.003. PMID 16214366.CS1 maint: Multiple names: authors list (link)
• Scherer SE, Muzny DM, Buhay CJ; et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan C, Moore BE, Cotman CW; et al. (2006). "Musashi1 antigen expression in human fetal germinal matrix development". Exp. Neurol. 201 (2): 515–8. doi:10.1016/j.expneurol.2006.04.023. PMID 16777095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)