MYL4

Myosin, light chain 4, alkali; atrial, embryonic
Identifiers
Symbols	MYL4 ; GT1; ALC1; AMLC; PRO1957
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20558
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYL4 210395 x at tn.png
File:PBB GE MYL4 210088 x at tn.png
File:PBB GE MYL4 216054 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin, light chain 4, alkali; atrial, embryonic, also known as MYL4, is a human gene.

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Further reading

• Rotter M, Zimmerman K, Poustka A; et al. (1991). "The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions". Nucleic Acids Res. 19 (7): 1497–504. PMID 2027757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seharaseyon J, Bober E, Hsieh CL; et al. (1990). "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location". Genomics. 7 (2): 289–93. PMID 2129532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zimmermann K, Kautz S, Hajdu G; et al. (1990). "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells". J. Mol. Biol. 211 (3): 505–13. PMID 2308163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seidel U, Bober E, Winter B; et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. PMID 2458299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arnold HH, Lohse P, Seidel U, Bober E (1989). "A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria". Eur. J. Biochem. 178 (1): 53–60. PMID 2849544.CS1 maint: Multiple names: authors list (link)
• Kurabayashi M, Komuro I, Tsuchimochi H; et al. (1988). "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones". J. Biol. Chem. 263 (27): 13930–6. PMID 3417683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strohman RC, Micou-Eastwood J, Glass CA, Matsuda R (1983). "Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain". Science. 221 (4614): 955–7. PMID 6879193.CS1 maint: Multiple names: authors list (link)
• Timson DJ, Trayer IP (1997). "The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex". FEBS Lett. 400 (1): 31–6. PMID 9000508.
• Timson DJ, Trayer HR, Trayer IP (1998). "The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function". Eur. J. Biochem. 255 (3): 654–62. PMID 9738905.CS1 maint: Multiple names: authors list (link)
• Timson DJ, Trayer HR, Smith KJ, Trayer IP (1999). "Size and charge requirements for kinetic modulation and actin binding by alkali 1-type myosin essential light chains". J. Biol. Chem. 274 (26): 18271–7. PMID 10373429.CS1 maint: Multiple names: authors list (link)
• Morano I (1999). "Tuning the human heart molecular motors by myosin light chains". J. Mol. Med. 77 (7): 544–55. PMID 10494800.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Arrell DK, Neverova I, Fraser H; et al. (2001). "Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1". Circ. Res. 89 (6): 480–7. PMID 11557734.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdelaziz AI, Pagel I, Schlegel WP; et al. (2006). "Human atrial myosin light chain 1 expression attenuates heart failure". Adv. Exp. Med. Biol. 565: 283–92, discussion 92, 405–15. PMID 16106982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)