MYO6

Myosin VI
File:PBB Protein MYO6 image.jpg PDB rendering based on 2bkh.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bkh​, 2bki​
Identifiers
Symbols	MYO6 ; DFNA22; DFNB37; KIAA0389
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56417
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYO6 203216 s at tn.png
File:PBB GE MYO6 203215 s at tn.png
File:PBB GE MYO6 210480 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin VI, also known as MYO6, is a human gene.

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM]

Further reading

• Buss F, Luzio JP, Kendrick-Jones J (2001). "Myosin VI, a new force in clathrin mediated endocytosis". FEBS Lett. 508 (3): 295–9. PMID 11728438.CS1 maint: Multiple names: authors list (link)
• Hasson T (2004). "Myosin VI: two distinct roles in endocytosis". J. Cell. Sci. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
• Avraham KB, Hasson T, Steel KP; et al. (1996). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nat. Genet. 11 (4): 369–75. doi:10.1038/ng1295-369. PMID 7493015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bement WM, Hasson T, Wirth JA; et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. PMID 8022818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Avraham KB, Hasson T, Sobe T; et al. (1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice". Hum. Mol. Genet. 6 (8): 1225–31. PMID 9259267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buss F, Kendrick-Jones J, Lionne C; et al. (1999). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation". J. Cell Biol. 143 (6): 1535–45. PMID 9852149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wells AL, Lin AW, Chen LQ; et al. (1999). "Myosin VI is an actin-based motor that moves backwards". Nature. 401 (6752): 505–8. doi:10.1038/46835. PMID 10519557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buss F, Arden SD, Lindsay M; et al. (2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". EMBO J. 20 (14): 3676–84. doi:10.1093/emboj/20.14.3676. PMID 11447109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Melchionda S, Ahituv N, Bisceglia L; et al. (2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss". Am. J. Hum. Genet. 69 (3): 635–40. PMID 11468689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshimura M, Homma K, Saito J; et al. (2001). "Dual regulation of mammalian myosin VI motor function". J. Biol. Chem. 276 (43): 39600–7. doi:10.1074/jbc.M105080200. PMID 11517222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rock RS, Rice SE, Wells AL; et al. (2002). "Myosin VI is a processive motor with a large step size". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13655–9. doi:10.1073/pnas.191512398. PMID 11707568.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue A, Sato O, Homma K, Ikebe M (2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.CS1 maint: Multiple names: authors list (link)
• Morris SM, Arden SD, Roberts RC; et al. (2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. PMID 11967127.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu H, Nash JE, Zamorano P, Garner CC (2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking". J. Biol. Chem. 277 (34): 30928–34. doi:10.1074/jbc.M203735200. PMID 12050163.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahmed ZM, Morell RJ, Riazuddin S; et al. (2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37". Am. J. Hum. Genet. 72 (5): 1315–22. PMID 12687499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aschenbrenner L, Lee T, Hasson T (2004). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Mol. Biol. Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMID 12857860.CS1 maint: Multiple names: authors list (link)