MYST1

MYST histone acetyltransferase 1
File:PBB Protein MYST1 image.jpg PDB rendering based on 1wgs.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wgs​, 2giv​, 2pq8​
Identifiers
Symbols	MYST1 ; FLJ14040; MOF; hMOF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41676
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYST1 221820 s at tn.png
File:PBB GE MYST1 214885 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MYST histone acetyltransferase 1, also known as MYST1, is a human gene.

The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000).[supplied by OMIM]

Further reading

• Rea S, Xouri G, Akhtar A (2007). "Males absent on the first (MOF): from flies to humans". Oncogene. 26 (37): 5385–94. doi:10.1038/sj.onc.1210607. PMID 17694080.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neal KC, Pannuti A, Smith ER, Lucchesi JC (2000). "A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF". Biochim. Biophys. Acta. 1490 (1–2): 170–4. PMID 10786633.CS1 maint: Multiple names: authors list (link)
• Kitabayashi I, Aikawa Y, Nguyen LA; et al. (2002). "Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein". EMBO J. 20 (24): 7184–96. doi:10.1093/emboj/20.24.7184. PMID 11742995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pelletier N, Champagne N, Stifani S, Yang XJ (2002). "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2". Oncogene. 21 (17): 2729–40. doi:10.1038/sj.onc.1205367. PMID 11965546.CS1 maint: Multiple names: authors list (link)
• Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (2003). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". J. Biol. Chem. 277 (52): 50860–6. doi:10.1074/jbc.M203839200. PMID 12397079.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta A, Sharma GG, Young CS; et al. (2005). "Involvement of human MOF in ATM function". Mol. Cell. Biol. 25 (12): 5292–305. doi:10.1128/MCB.25.12.5292-5305.2005. PMID 15923642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dou Y, Milne TA, Tackett AJ; et al. (2005). "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j.cell.2005.04.031. PMID 15960975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taipale M, Rea S, Richter K; et al. (2005). "hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells". Mol. Cell. Biol. 25 (15): 6798–810. doi:10.1128/MCB.25.15.6798-6810.2005. PMID 16024812.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cereseto A, Manganaro L, Gutierrez MI; et al. (2005). "Acetylation of HIV-1 integrase by p300 regulates viral integration". EMBO J. 24 (17): 3070–81. doi:10.1038/sj.emboj.7600770. PMID 16096645.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith ER, Cayrou C, Huang R; et al. (2005). "A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16". Mol. Cell. Biol. 25 (21): 9175–88. doi:10.1128/MCB.25.21.9175-9188.2005. PMID 16227571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Topper M, Luo Y, Zhadina M; et al. (2007). "Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication". J. Virol. 81 (6): 3012–7. doi:10.1128/JVI.02257-06. PMID 17182677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)