Whipple's disease

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Whipple's disease
light microscopy of small intestine;Whipples Disease: enlarged villus with abundant macrophages
ICD-10 K90.8
ICD-9 040.2
DiseasesDB 14124
MedlinePlus 000209
MeSH D008061

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy; untreated the disease is ultimately fatal.

Mnemonics

W H I P P L E S

Symptoms

Diagnosis

Common clinical signs and symptoms of Whipple's disease include weight loss, diarrhea, joint pain or arthritis, fever, and adenopathy. Diagnosis is made by intestinal biopsy, which reveals presence of the organism as PAS-positive macrophage inclusions. Immunohistochemical staining for antibodies against T. whipplei has been used to detect the organism in a variety if tissues, and a confirmatory PCR-based assay is also available.

Endoscopy of the duodenum and jejunum can reveal pale yellow shaggy mucosa with erythematous eroded patches in patients with classic intestinal Whipple's disease, and small bowel X-rays may show some thickened folds.

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References

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