NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2)
Identifiers
Symbols	NAB2 ; MADER; MGC75085
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4353
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NAB2 212803 at tn.png
File:PBB GE NAB2 216017 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NGFI-A binding protein 2 (EGR1 binding protein 2), also known as NAB2, is a human gene.

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Further reading

• Kirsch KH, Korradi Y, Johnson JP (1996). "Mader: a novel nuclear protein over expressed in human melanomas". Oncogene. 12 (5): 963–71. PMID 8649813.CS1 maint: Multiple names: authors list (link)
• Svaren J, Sevetson BR, Apel ED; et al. (1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol. Cell. Biol. 16 (7): 3545–53. PMID 8668170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Svaren J, Apel ED, Simburger KS; et al. (1997). "The Nab2 and Stat6 genes share a common transcription termination region". Genomics. 41 (1): 33–9. doi:10.1006/geno.1997.4609. PMID 9126479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qu Z, Wolfraim LA, Svaren J; et al. (1998). "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells". J. Cell Biol. 142 (4): 1075–82. PMID 9722618.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Svaren J, Sevetson BR, Golda T; et al. (1998). "Novel mutants of NAB corepressors enhance activation by Egr transactivators". EMBO J. 17 (20): 6010–9. doi:10.1093/emboj/17.20.6010. PMID 9774344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdulkadir SA, Qu Z, Garabedian E; et al. (2001). "Impaired prostate tumorigenesis in Egr1-deficient mice". Nat. Med. 7 (1): 101–7. doi:10.1038/83231. PMID 11135623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdulkadir SA, Carbone JM, Naughton CK; et al. (2001). "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma". Hum. Pathol. 32 (9): 935–9. doi:10.1053/hupa.2001.27102. PMID 11567222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venken K, Di Maria E, Bellone E; et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. PMID 12030330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lucerna M, Mechtcheriakova D, Kadl A; et al. (2003). "NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells". J. Biol. Chem. 278 (13): 11433–40. doi:10.1074/jbc.M204937200. PMID 12427750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumbrink J, Gerlinger M, Johnson JP (2006). "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop". J. Biol. Chem. 280 (52): 42785–93. doi:10.1074/jbc.M511079200. PMID 16260776.CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srinivasan R, Mager GM, Ward RM; et al. (2006). "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex". J. Biol. Chem. 281 (22): 15129–37. doi:10.1074/jbc.M600775200. PMID 16574654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)