NCK1

NCK adaptor protein 1
File:PBB Protein NCK1 image.jpg PDB rendering based on 2ci8.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ci8​, 2ci9​, 2cub​
Identifiers
Symbols	NCK1 ; MGC12668; NCK; NCKalpha
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38148
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NCK1 204725 s at tn.png
File:PBB GE NCK1 211063 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NCK adaptor protein 1, also known as NCK1, is a human gene.

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS.

See also

• Adaptor protein
• Receptor tyrosine kinase
• Ras

Further reading

• Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes". J. Dermatol. Sci. 23 (2): 75–86. PMID 10808124.CS1 maint: Multiple names: authors list (link)
• Park D, Rhee SG (1992). "Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP". Mol. Cell. Biol. 12 (12): 5816–23. PMID 1333046.
• Meisenhelder J, Hunter T (1992). "The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment". Mol. Cell. Biol. 12 (12): 5843–56. PMID 1448108.
• Lehmann JM, Riethmüller G, Johnson JP (1990). "Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3". Nucleic Acids Res. 18 (4): 1048. PMID 2107526.CS1 maint: Multiple names: authors list (link)
• Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC (1994). "Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene". J. Biol. Chem. 269 (26): 17363–6. PMID 7517397.CS1 maint: Multiple names: authors list (link)
• Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Mol. Cell. Biol. 15 (10): 5725–31. PMID 7565724.CS1 maint: Multiple names: authors list (link)
• Chou MM, Hanafusa H (1995). "A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain". J. Biol. Chem. 270 (13): 7359–64. PMID 7706279.
• Huebner K, Kastury K, Druck T; et al. (1995). "Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2)". Genomics. 22 (2): 281–7. PMID 7806213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu Q, Milfay D, Williams LT (1995). "Binding of NCK to SOS and activation of ras-dependent gene expression". Mol. Cell. Biol. 15 (3): 1169–74. PMID 7862111.CS1 maint: Multiple names: authors list (link)
• Vorobieva N, Protopopov A, Protopopova M; et al. (1994). "Localization of human ARF2 and NCK genes and 13 other NotI-linking clones to chromosome 3 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 68 (1–2): 91–4. PMID 7956370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitamura T, Kitamura Y, Yonezawa K; et al. (1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck". Biochem. Biophys. Res. Commun. 219 (2): 509–14. PMID 8605018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okada S, Pessin JE (1996). "Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor". J. Biol. Chem. 271 (41): 25533–8. PMID 8810325.
• Bokoch GM, Wang Y, Bohl BP; et al. (1996). "Interaction of the Nck adapter protein with p21-activated kinase (PAK1)". J. Biol. Chem. 271 (42): 25746–9. PMID 8824201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minegishi M, Tachibana K, Sato T; et al. (1996). "Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". J. Exp. Med. 184 (4): 1365–75. PMID 8879209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roche S, McGlade J, Jones M; et al. (1996). "Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways". EMBO J. 15 (18): 4940–8. PMID 8890167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quilliam LA, Lambert QT, Mickelson-Young LA; et al. (1997). "Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling". J. Biol. Chem. 271 (46): 28772–6. PMID 8910519.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lussier G, Larose L (1997). "A casein kinase I activity is constitutively associated with Nck". J. Biol. Chem. 272 (5): 2688–94. PMID 9006905.
• Lawe DC, Hahn C, Wong AJ (1997). "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223–31. doi:10.1038/sj.onc.1200821. PMID 9010224.CS1 maint: Multiple names: authors list (link)
• Lu W, Katz S, Gupta R, Mayer BJ (1997). "Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck". Curr. Biol. 7 (2): 85–94. PMID 9024622.CS1 maint: Multiple names: authors list (link)
• Su YC, Han J, Xu S; et al. (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain". EMBO J. 16 (6): 1279–90. doi:10.1093/emboj/16.6.1279. PMID 9135144.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)