NGLY1

N-glycanase 1
File:PBB Protein NGLY1 image.jpg PDB rendering based on 2ccq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ccq​, 2cm0​, 2d5u​, 2hpj​, 2hpl​
Identifiers
Symbols	NGLY1 ; FLJ11005; FLJ12409; PNG1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10117
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE NGLY1 220742 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

N-glycanase 1, also known as NGLY1, is a human gene.

Further reading

• Suzuki T, Park H, Hollingsworth NM; et al. (2000). "PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase". J. Cell Biol. 149 (5): 1039–52. PMID 10831608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park H, Suzuki T, Lennarz WJ (2001). "Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11163–8. doi:10.1073/pnas.201393498. PMID 11562482.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blom D, Hirsch C, Stern P; et al. (2005). "A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised". EMBO J. 23 (3): 650–8. doi:10.1038/sj.emboj.7600090. PMID 14749736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katiyar S, Li G, Lennarz WJ (2004). "A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13774–9. doi:10.1073/pnas.0405663101. PMID 15358861.CS1 maint: Multiple names: authors list (link)
• McNeill H, Knebel A, Arthur JS; et al. (2005). "A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs". Biochem. J. 384 (Pt 2): 391–400. doi:10.1042/BJ20041498. PMID 15362974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Misaghi S, Pacold ME, Blom D; et al. (2005). "Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover". Chem. Biol. 11 (12): 1677–87. doi:10.1016/j.chembiol.2004.11.010. PMID 15610852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katiyar S, Joshi S, Lennarz WJ (2006). "The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum". Mol. Biol. Cell. 16 (10): 4584–94. doi:10.1091/mbc.E05-04-0345. PMID 16055502.CS1 maint: Multiple names: authors list (link)
• Allen MD, Buchberger A, Bycroft M (2006). "The PUB domain functions as a p97 binding module in human peptide N-glycanase". J. Biol. Chem. 281 (35): 25502–8. doi:10.1074/jbc.M601173200. PMID 16807242.CS1 maint: Multiple names: authors list (link)
• Altrich-VanLith ML, Ostankovitch M, Polefrone JM; et al. (2007). "Processing of a class I-restricted epitope from tyrosinase requires peptide N-glycanase and the cooperative action of endoplasmic reticulum aminopeptidase 1 and cytosolic proteases". J. Immunol. 177 (8): 5440–50. PMID 17015730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)