NLGN1
| Neuroligin 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | NLGN1 ; KIAA1070; MGC45115 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 56690 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NLGN1 205893 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Neuroligin 1, also known as NLGN1, is a human gene.[1]
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.[1]
See also
References
Further reading
- Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. PMID 10996085.
- Ichtchenko K, Hata Y, Nguyen T; et al. (1995). "Neuroligin 1: a splice site-specific ligand for beta-neurexins". Cell. 81 (3): 435–43. PMID 7736595.
- Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. PMID 8576240.
- Irie M, Hata Y, Takeuchi M; et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. PMID 9278515.
- Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.
- Nagase T, Kikuno R, Ishikawa K; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. PMID 10819331.
- Scheiffele P, Fan J, Choih J; et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. PMID 10892652.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Comoletti D, Flynn R, Jennings LL; et al. (2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. 278 (50): 50497–505. doi:10.1074/jbc.M306803200. PMID 14522992.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Chubykin AA, Liu X, Comoletti D; et al. (2005). "Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism". J. Biol. Chem. 280 (23): 22365–74. doi:10.1074/jbc.M410723200. PMID 15797875.
- Muzny DM, Scherer SE, Kaul R; et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.
- Li X, Zhang J, Cao Z; et al. (2006). "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin". Protein Sci. 15 (9): 2149–58. doi:10.1110/ps.062087506. PMID 16882988.
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