NLGN3

Neuroligin 3
Identifiers
Symbols	NLGN3 ; ASPGX1; AUTSX1; HNL3; KIAA1480
External IDs	Template:OMIM5 Template:MGI HomoloGene: 23133
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE NLGN3 219726 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Neuroligin 3, also known as NLGN3, is a human gene.

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.

Further reading

• Missler M, Fernandez-Chacon R, Südhof TC (1998). "The making of neurexins". J. Neurochem. 71 (4): 1339–47. PMID 9751164.CS1 maint: Multiple names: authors list (link)
• Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. PMID 10996085.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. PMID 8576240.CS1 maint: Multiple names: authors list (link)
• Irie M, Hata Y, Takeuchi M; et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. PMID 9278515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–9. PMID 9325340.
• Philibert RA, Winfield SL, Sandhu HK; et al. (2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. PMID 10767552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa K; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. PMID 10819331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gilbert M, Smith J, Roskams AJ, Auld VJ (2001). "Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia". Glia. 34 (3): 151–64. PMID 11329178.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jamain S, Quach H, Betancur C; et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMID 12669065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vincent JB, Kolozsvari D, Roberts WS; et al. (2005). "Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 82–4. doi:10.1002/ajmg.b.30069. PMID 15274046.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gauthier J, Bonnel A, St-Onge J; et al. (2005). "NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 132 (1): 74–5. doi:10.1002/ajmg.b.30066. PMID 15389766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan J, Oliveira G, Coutinho A; et al. (2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Mol. Psychiatry. 10 (4): 329–32. doi:10.1038/sj.mp.4001629. PMID 15622415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blasi F, Bacchelli E, Pesaresi G; et al. (2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (3): 220–1. doi:10.1002/ajmg.b.30287. PMID 16508939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Talebizadeh Z, Lam DY, Theodoro MF; et al. (2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". J. Med. Genet. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMID 16648374.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamakawa H, Oyama S, Mitsuhashi H; et al. (2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochem. Biophys. Res. Commun. 355 (1): 41–6. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)