NMT2

N-myristoyltransferase 2
Identifiers
Symbols	NMT2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68416
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NMT2 205005 s at tn.png
File:PBB GE NMT2 205006 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

N-myristoyltransferase 2, also known as NMT2, is a human gene.

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.

Further reading

• Pal R, Reitz MS, Tschachler E; et al. (1990). "Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly". AIDS Res. Hum. Retroviruses. 6 (6): 721–30. PMID 2194551.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bryant M, Ratner L (1990). "Myristoylation-dependent replication and assembly of human immunodeficiency virus 1". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 523–7. PMID 2405382.
• Tashiro A, Shoji S, Kubota Y (1990). "Antimyristoylation of the gag proteins in the human immunodeficiency virus-infected cells with N-myristoyl glycinal diethylacetal resulted in inhibition of virus production". Biochem. Biophys. Res. Commun. 165 (3): 1145–54. PMID 2692561.CS1 maint: Multiple names: authors list (link)
• Goddard C, Aquino A, Glazer RI, Felsted RL (1989). "Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein". Eur. J. Biochem. 182 (2): 323–6. PMID 2737204.CS1 maint: Multiple names: authors list (link)
• Göttlinger HG, Sodroski JG, Haseltine WA (1989). "Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5781–5. PMID 2788277.CS1 maint: Multiple names: authors list (link)
• Lee PP, Linial ML (1994). "Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal". J. Virol. 68 (10): 6644–54. PMID 7521919.
• Zhou W, Parent LJ, Wills JW, Resh MD (1994). "Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids". J. Virol. 68 (4): 2556–69. PMID 8139035.CS1 maint: Multiple names: authors list (link)
• Morikawa Y, Hinata S, Tomoda H; et al. (1996). "Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding". J. Biol. Chem. 271 (5): 2868–73. PMID 8576268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou W, Resh MD (1997). "Differential membrane binding of the human immunodeficiency virus type 1 matrix protein". J. Virol. 70 (12): 8540–8. PMID 8970978.
• Spearman P, Horton R, Ratner L, Kuli-Zade I (1997). "Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism". J. Virol. 71 (9): 6582–92. PMID 9261380.CS1 maint: Multiple names: authors list (link)
• Furuishi K, Matsuoka H, Takama M; et al. (1997). "Blockage of N-myristoylation of HIV-1 gag induces the production of impotent progeny virus". Biochem. Biophys. Res. Commun. 237 (3): 504–11. doi:10.1006/bbrc.1997.7178. PMID 9299393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giang DK, Cravatt BF (1998). "A second mammalian N-myristoyltransferase". J. Biol. Chem. 273 (12): 6595–8. PMID 9506952.
• Hermida-Matsumoto L, Resh MD (1999). "Human immunodeficiency virus type 1 protease triggers a myristoyl switch that modulates membrane binding of Pr55(gag) and p17MA". J. Virol. 73 (3): 1902–8. PMID 9971769.
• Paillart JC, Göttlinger HG (1999). "Opposing effects of human immunodeficiency virus type 1 matrix mutations support a myristyl switch model of gag membrane targeting". J. Virol. 73 (4): 2604–12. PMID 10074105.
• Ono A, Freed EO (1999). "Binding of human immunodeficiency virus type 1 Gag to membrane: role of the matrix amino terminus". J. Virol. 73 (5): 4136–44. PMID 10196310.
• Shiraishi T, Misumi S, Takama M; et al. (2001). "Myristoylation of human immunodeficiency virus type 1 gag protein is required for efficient env protein transportation to the surface of cells". Biochem. Biophys. Res. Commun. 282 (5): 1201–5. doi:10.1006/bbrc.2001.4696. PMID 11302743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolluri SK, Balduf C, Hofmann M, Göttlicher M (2002). "Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2". Cancer Res. 61 (23): 8534–9. PMID 11731439.CS1 maint: Multiple names: authors list (link)
• Lindwasser OW, Resh MD (2002). "Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral budding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13037–42. doi:10.1073/pnas.212409999. PMID 12244217.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouamr F, Scarlata S, Carter C (2003). "Role of myristylation in HIV-1 Gag assembly". Biochemistry. 42 (21): 6408–17. doi:10.1021/bi020692z. PMID 12767222.CS1 maint: Multiple names: authors list (link)