NPAT (gene)

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Nuclear protein, ataxia-telangiectasia locus
Identifiers
Symbols NPAT ; E14
External IDs Template:OMIM5 Template:MGI HomoloGene1888
RNA expression pattern
File:PBB GE NPAT 209798 at tn.png
File:PBB GE NPAT 211584 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Nuclear protein, ataxia-telangiectasia locus, also known as NPAT, is a human gene.[1]


References

  1. "Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus".

Further reading

  • Imai T, Yamauchi M, Seki N; et al. (1996). "Identification and characterization of a new gene physically linked to the ATM gene". Genome Res. 6 (5): 439–47. PMID 8743993.
  • Byrd PJ, McConville CM, Cooper P; et al. (1996). "Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia". Hum. Mol. Genet. 5 (1): 145–9. PMID 8789452.
  • Byrd PJ, Cooper PR, Stankovic T; et al. (1997). "A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies". Hum. Mol. Genet. 5 (11): 1785–91. PMID 8923007.
  • Imai T, Sugawara T, Nishiyama A; et al. (1997). "The structure and organization of the human NPAT gene". Genomics. 42 (3): 388–92. PMID 9205109.
  • Zhao J, Dynlacht B, Imai T; et al. (1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry". Genes Dev. 12 (4): 456–61. PMID 9472014.
  • Zhao J, Kennedy BK, Lawrence BD; et al. (2000). "NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription". Genes Dev. 14 (18): 2283–97. PMID 10995386.
  • Sagara M, Takeda E, Nishiyama A; et al. (2004). "Characterization of functional regions for nuclear localization of NPAT". J. Biochem. 132 (6): 875–9. PMID 12473189.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Gao G, Bracken AP, Burkard K; et al. (2003). "NPAT expression is regulated by E2F and is essential for cell cycle progression". Mol. Cell. Biol. 23 (8): 2821–33. PMID 12665581.
  • Wei Y, Jin J, Harper JW (2003). "The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain". Mol. Cell. Biol. 23 (10): 3669–80. PMID 12724424.
  • Zheng L, Roeder RG, Luo Y (2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell. 114 (2): 255–66. PMID 12887926.
  • Ye X, Wei Y, Nalepa G, Harper JW (2003). "The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells". Mol. Cell. Biol. 23 (23): 8586–600. PMID 14612403.
  • Wang A, Ikura T, Eto K, Ota MS (2005). "Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry". Biochem. Biophys. Res. Commun. 325 (4): 1509–16. doi:10.1016/j.bbrc.2004.10.198. PMID 15555599.
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
  • Kalla C, Scheuermann MO, Kube I; et al. (2007). "Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B". Eur. J. Cancer. 43 (8): 1328–35. doi:10.1016/j.ejca.2007.02.005. PMID 17449237.
  • Medina R, van der Deen M, Miele-Chamberland A; et al. (2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes". Cancer Res. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.

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