NSFL1C
| NSFL1 (p97) cofactor (p47) | |||||||||||||
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File:PBB Protein NSFL1C image.jpg PDB rendering based on 1i42. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NSFL1C ; p47; MGC3347; UBXD10; dJ776F14.1 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 41114 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE NSFL1C 217830 s at tn.png | |||||||||||||
| File:PBB GE NSFL1C 220248 x at tn.png | |||||||||||||
| File:PBB GE NSFL1C 217831 s at tn.png | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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NSFL1 (p97) cofactor (p47), also known as NSFL1C, is a human gene.[1]
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Kondo H, Rabouille C, Newman R; et al. (1997). "p47 is a cofactor for p97-mediated membrane fusion". Nature. 388 (6637): 75–8. doi:10.1038/40411. PMID 9214505.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Rabouille C, Kondo H, Newman R; et al. (1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell. 92 (5): 603–10. PMID 9506515.
- Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
- Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Meyer HH, Wang Y, Warren G (2002). "Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4". EMBO J. 21 (21): 5645–52. PMID 12411482.
- Uchiyama K, Jokitalo E, Kano F; et al. (2003). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". J. Cell Biol. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMID 12473691.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Nagahama M, Suzuki M, Hamada Y; et al. (2003). "SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation". Mol. Biol. Cell. 14 (1): 262–73. doi:10.1091/mbc.02-07-0115. PMID 12529442.
- Uchiyama K, Jokitalo E, Lindman M; et al. (2003). "The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle". J. Cell Biol. 161 (6): 1067–79. doi:10.1083/jcb.200303048. PMID 12810701.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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