NUB1

Negative regulator of ubiquitin-like proteins 1
File:PBB Protein NUB1 image.jpg PDB rendering based on 1wju.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wju​
Identifiers
Symbols	NUB1 ; BS4; NUB1L; NYREN18
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41108
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE NUB1 gnf1h00209 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Negative regulator of ubiquitin-like proteins 1, also known as NUB1, is a human gene.

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM]

Further reading

• Scanlan MJ, Gordan JD, Williamson B; et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. PMID 10508479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kito K, Yeh ET, Kamitani T (2001). "NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression". J. Biol. Chem. 276 (23): 20603–9. doi:10.1074/jbc.M100920200. PMID 11259415.CS1 maint: Multiple names: authors list (link)
• Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET (2002). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1". J. Biol. Chem. 276 (49): 46655–60. doi:10.1074/jbc.M108636200. PMID 11585840.CS1 maint: Multiple names: authors list (link)
• Akey DT, Zhu X, Dyer M; et al. (2003). "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Hum. Mol. Genet. 11 (22): 2723–33. PMID 12374762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka T, Kawashima H, Yeh ET, Kamitani T (2003). "Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L". J. Biol. Chem. 278 (35): 32905–13. doi:10.1074/jbc.M212057200. PMID 12816948.CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reuter TY, Medhurst AL, Waisfisz Q; et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. PMID 14499622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Spuy J, Kim JH, Yu YS; et al. (2003). "The expression of the Leber congenital amaurosis protein AIPL1 coincides with rod and cone photoreceptor development". Invest. Ophthalmol. Vis. Sci. 44 (12): 5396–403. PMID 14638743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hipp MS, Raasi S, Groettrup M, Schmidtke G (2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation". J. Biol. Chem. 279 (16): 16503–10. doi:10.1074/jbc.M310114200. PMID 14757770.CS1 maint: Multiple names: authors list (link)
• Tanaka T, Yeh ET, Kamitani T (2004). "NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis". Eur. J. Biochem. 271 (5): 972–82. PMID 15009209.CS1 maint: Multiple names: authors list (link)
• Kanaya K, Sohocki MM, Kamitani T (2004). "Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis". Biochem. Biophys. Res. Commun. 317 (3): 768–73. doi:10.1016/j.bbrc.2004.03.108. PMID 15081406.CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Spuy J, Cheetham ME (2005). "The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments". J. Biol. Chem. 279 (46): 48038–47. doi:10.1074/jbc.M407871200. PMID 15347646.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidtke G, Kalveram B, Weber E; et al. (2006). "The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10". J. Biol. Chem. 281 (29): 20045–54. doi:10.1074/jbc.M603063200. PMID 16707496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanji K, Tanaka T, Mori F; et al. (2006). "NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1". Am. J. Pathol. 169 (2): 553–65. PMID 16877356.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)