NUTF2

Nuclear transport factor 2
File:PBB Protein NUTF2 image.jpg PDB rendering based on 1a2k.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a2k​, 1ar0​, 1ask​, 1gy5​, 1gy6​, 1jb2​, 1jb4​, 1jb5​, 1oun​, 1qma​, 1u5o​
Identifiers
Symbols	NUTF2 ; NTF2; PP15
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38101
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nuclear transport factor 2, also known as NUTF2, is a human gene.

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.

Further reading

• Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. PMID 9562972.
• Stewart M (2001). "Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2)". Cell Struct. Funct. 25 (4): 217–25. PMID 11129791.
• Grundmann U, Nerlich C, Rein T; et al. (1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res. 16 (10): 4721. PMID 3380696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bohn H, Johannsen R, Kraus W (1981). "[New placental protein (PP15) with immunosuppressive properties (author's transl)]". Arch. Gynecol. 230 (2): 167–72. PMID 7458421.CS1 maint: Multiple names: authors list (link)
• Paschal BM, Gerace L (1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J. Cell Biol. 129 (4): 925–37. PMID 7744965.
• Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. PMID 8707840.CS1 maint: Multiple names: authors list (link)
• Bullock TL, Clarkson WD, Kent HM, Stewart M (1996). "The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)". J. Mol. Biol. 260 (3): 422–31. PMID 8757804.CS1 maint: Multiple names: authors list (link)
• Clarkson WD, Corbett AH, Paschal BM; et al. (1997). "Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran". J. Mol. Biol. 272 (5): 716–30. doi:10.1006/jmbi.1997.1255. PMID 9368653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stewart M, Kent HM, McCoy AJ (1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–46. doi:10.1006/jmbi.1997.1602. PMID 9533885.CS1 maint: Multiple names: authors list (link)
• Ribbeck K, Lipowsky G, Kent HM; et al. (1999). "NTF2 mediates nuclear import of Ran". EMBO J. 17 (22): 6587–98. doi:10.1093/emboj/17.22.6587. PMID 9822603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steggerda SM, Black BE, Paschal BM (2000). "Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran". Mol. Biol. Cell. 11 (2): 703–19. PMID 10679025.CS1 maint: Multiple names: authors list (link)
• Freire J, Covelo G, Sarandeses C; et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol. 79 (2): 123–31. PMID 11310559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cushman I, Bowman BR, Sowa ME; et al. (2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–10. doi:10.1016/j.jmb.2004.09.043. PMID 15522285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)