ODF1

Outer dense fiber of sperm tails 1
Identifiers
Symbols	ODF1 ; HSPB10; MGC129928; MGC129929; ODF; ODF2; ODF27; ODFP; ODFPG; ODFPGA; ODFPGB; RT7; SODF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7456
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ODF1 214485 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Outer dense fiber of sperm tails 1, also known as ODF1, is a human gene.

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.

Further reading

• Kierszenbaum AL (2002). "Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells". Mol. Reprod. Dev. 61 (1): 1–2. doi:10.1002/mrd.1124. PMID 11774369.
• Henkel R, Stalf T, Miska W (1992). "Isolation and partial characterization of the outer dense fiber proteins from human spermatozoa". Biol. Chem. Hoppe-Seyler. 373 (8): 685–9. PMID 1418683.CS1 maint: Multiple names: authors list (link)
• Hofferbert S, Burfeind P, Hoyer-Fender S; et al. (1994). "A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype". Hum. Mol. Genet. 2 (12): 2167–70. PMID 8111388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gastmann O, Burfeind P, Günther E; et al. (1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol. Reprod. Dev. 36 (4): 407–18. doi:10.1002/mrd.1080360402. PMID 8305202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burmester S, Hoyer-Fender S (1997). "Transcription and translation of the outer dense fiber gene (Odf1) during spermiogenesis in the rat. A study by in situ analyses and polysome fractionation". Mol. Reprod. Dev. 45 (1): 10–20. doi:10.1002/(SICI)1098-2795(199609)45:1<10::AID-MRD2>3.0.CO;2-V. PMID 8873064.
• Shao X, van der Hoorn FA (1997). "Self-interaction of the major 27-kilodalton outer dense fiber protein is in part mediated by a leucine zipper domain in the rat". Biol. Reprod. 55 (6): 1343–50. PMID 8949892.
• Shao X, Tarnasky HA, Schalles U; et al. (1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J. Biol. Chem. 272 (10): 6105–13. PMID 9045620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shao X, Tarnasky HA, Lee JP; et al. (1999). "Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme". Dev. Biol. 211 (1): 109–23. doi:10.1006/dbio.1999.9297. PMID 10373309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petersen C, Füzesi L, Hoyer-Fender S (1999). "Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa". Mol. Hum. Reprod. 5 (7): 627–35. PMID 10381817.CS1 maint: Multiple names: authors list (link)
• Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–6. doi:10.1002/mrd.1047. PMID 11468777.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA (2003). "Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1". Biol. Reprod. 68 (2): 543–52. PMID 12533418.CS1 maint: Multiple names: authors list (link)
• Bhullar B, Zhang Y, Junco A; et al. (2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". J. Biol. Chem. 278 (18): 16159–68. doi:10.1074/jbc.M213126200. PMID 12594206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)