OS9 (gene)
| Amplified in osteosarcoma | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | OS9 ; | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 31409 | ||||||||
| |||||||||
| RNA expression pattern | |||||||||
| File:PBB GE OS9 215399 s at tn.png | |||||||||
| File:PBB GE OS9 200714 x at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Amplified in osteosarcoma, also known as OS9, is a human gene.[1]
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
References
Further reading
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Baek JH, Mahon PC, Oh J; et al. (2005). "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha". Mol. Cell. 17 (4): 503–12. doi:10.1016/j.molcel.2005.01.011. PMID 15721254.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
- Vigneron N, Ooms A, Morel S; et al. (2003). "Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma". Cancer Immun. 2: 9. PMID 12747754.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Litovchick L, Friedmann E, Shaltiel S (2002). "A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta". J. Biol. Chem. 277 (37): 34413–23. doi:10.1074/jbc.M203986200. PMID 12093806.
- Friedmann E, Salzberg Y, Weinberger A; et al. (2002). "YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins". J. Biol. Chem. 277 (38): 35274–81. doi:10.1074/jbc.M201044200. PMID 12077121.
- Nakayama T, Yaoi T, Kuwajima G; et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Lett. 453 (1–2): 77–80. PMID 10403379.
- Kimura Y, Nakazawa M, Yamada M (1998). "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines". J. Biochem. 123 (5): 876–82. PMID 9562620.
- Kimura Y, Nakazawa M, Tsuchiya N; et al. (1998). "Genomic organization of the OS-9 gene amplified in human sarcomas". J. Biochem. 122 (6): 1190–5. PMID 9498564.
- Elkahloun AG, Krizman DB, Wang Z; et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
- Su YA, Hutter CM, Trent JM, Meltzer PS (1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Mol. Carcinog. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |