P53 upregulated modulator of apoptosis

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Template:Protbox The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.

See also

References

  1. ↑ Nakano, K. (2001). "PUMA, a Novel Proaptotic Gene, is Induced by p53". Molecular Cell. 7: 683–694. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)


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