PARG

Poly (ADP-ribose) glycohydrolase
Identifiers
Symbols	PARG ; PARG99
External IDs	Template:OMIM5 Template:MGI HomoloGene: 50532
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Poly (ADP-ribose) glycohydrolase, also known as PARG, is a human gene.

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Further reading

• Bonicalzi ME, Haince JF, Droit A, Poirier GG (2005). "Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when?". Cell. Mol. Life Sci. 62 (7–8): 739–50. doi:10.1007/s00018-004-4505-1. PMID 15868399.CS1 maint: Multiple names: authors list (link)
• Uchida K, Suzuki H, Maruta H; et al. (1993). "Preferential degradation of protein-bound (ADP-ribose)n by nuclear poly(ADP-ribose) glycohydrolase from human placenta". J. Biol. Chem. 268 (5): 3194–200. PMID 8428996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin W, Amé JC, Aboul-Ela N; et al. (1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. PMID 9115250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winstall E, Affar EB, Shah R; et al. (1999). "Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein". Exp. Cell Res. 246 (2): 395–8. doi:10.1006/excr.1998.4321. PMID 9925755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 269–70. PMID 10449915.CS1 maint: Multiple names: authors list (link)
• Affar EB, Germain M, Winstall E; et al. (2001). "Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis". J. Biol. Chem. 276 (4): 2935–42. doi:10.1074/jbc.M007269200. PMID 11053413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohashi S, Kanai M, Hanai S; et al. (2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells". Biochem. Biophys. Res. Commun. 307 (4): 915–21. PMID 12878198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meyer RG, Meyer-Ficca ML, Jacobson EL, Jacobson MK (2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)". Gene. 314: 181–90. PMID 14527731.CS1 maint: Multiple names: authors list (link)
• Golovanov AP, Barillà D, Golovanova M; et al. (2004). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure". Mol. Microbiol. 50 (4): 1141–53. PMID 14622405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Keil C, Petermann E, Oei SL (2004). "Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts". Arch. Biochem. Biophys. 425 (1): 115–21. doi:10.1016/j.abb.2004.02.024. PMID 15081900.CS1 maint: Multiple names: authors list (link)
• Meyer-Ficca ML, Meyer RG, Coyle DL; et al. (2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments". Exp. Cell Res. 297 (2): 521–32. doi:10.1016/j.yexcr.2004.03.050. PMID 15212953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Putt KS, Hergenrother PJ (2005). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation". Anal. Biochem. 333 (2): 256–64. doi:10.1016/j.ab.2004.04.032. PMID 15450800.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gagné JP, Bonicalzi ME, Gagné P; et al. (2006). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles". Biochem. J. 392 (Pt 3): 499–509. doi:10.1042/BJ20050792. PMID 16117724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blenn C, Althaus FR, Malanga M (2006). "Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death". Biochem. J. 396 (3): 419–29. doi:10.1042/BJ20051696. PMID 16526943.CS1 maint: Multiple names: authors list (link)
• Keil C, Gröbe T, Oei SL (2006). "MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1". J. Biol. Chem. 281 (45): 34394–405. doi:10.1074/jbc.M606470200. PMID 16963444.CS1 maint: Multiple names: authors list (link)
• Meyer RG, Meyer-Ficca ML, Whatcott CJ; et al. (2007). "Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity". Exp. Cell Res. 313 (13): 2920–36. doi:10.1016/j.yexcr.2007.03.043. PMID 17509564.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)