PCGF2

Polycomb group ring finger 2
File:PBB Protein PCGF2 image.jpg PDB rendering based on 2h0d.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2h0d​
Identifiers
Symbols	PCGF2 ; MEL-18; MGC10545; RNF110; ZNF144
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5174
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PCGF2 213551 x at tn.png
File:PBB GE PCGF2 203792 x at tn.png
File:PBB GE PCGF2 203793 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Polycomb group ring finger 2, also known as PCGF2, is a human gene.

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

Further reading

• Ishida A, Asano H, Hasegawa M; et al. (1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. PMID 8325509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura M, Koseki Y, Yamashita M; et al. (2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene". Immunity. 15 (2): 275–87. PMID 11520462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyazaki K, Inoue H, Onai N; et al. (2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18". Immunol. Lett. 80 (2): 139–43. PMID 11750047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levine SS, Weiss A, Erdjument-Bromage H; et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki M, Mizutani-Koseki Y, Fujimura Y; et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. PMID 12183370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuo F, Yano K, Saito H; et al. (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines". Breast Cancer. 9 (1): 33–8. PMID 12196719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silva J, García JM, Peña C; et al. (2007). "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clin. Cancer Res. 12 (23): 6929–36. doi:10.1158/1078-0432.CCR-06-0788. PMID 17145810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo WJ, Datta S, Band V, Dimri GP (2007). "Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins". Mol. Biol. Cell. 18 (2): 536–46. doi:10.1091/mbc.E06-05-0447. PMID 17151361.CS1 maint: Multiple names: authors list (link)
• Wiederschain D, Chen L, Johnson B; et al. (2007). "Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis". Mol. Cell. Biol. 27 (13): 4968–79. doi:10.1128/MCB.02244-06. PMID 17452456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo WJ, Zeng MS, Yadav A; et al. (2007). "Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells". Cancer Res. 67 (11): 5083–9. doi:10.1158/0008-5472.CAN-06-4368. PMID 17545584.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Szafranski K, Schindler S, Taudien S; et al. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)