PCNT

Pericentrin (kendrin)
Identifiers
Symbols	PCNT ; KEN; PCN; PCNT2; PCNTB; PCTN2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86942
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PCNT 203660 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pericentrin (kendrin), also known as PCNT, is a human gene.

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Gos A, Morris MA, Antonarakis SE (1996). "Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter". Genomics. 35 (3): 620–4. doi:10.1006/geno.1996.0411. PMID 8812505.CS1 maint: Multiple names: authors list (link)
• Ishikawa K, Nagase T, Nakajima D; et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. PMID 9455477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diviani D, Langeberg LK, Doxsey SJ, Scott JD (2000). "Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain". Curr. Biol. 10 (7): 417–20. PMID 10753751.CS1 maint: Multiple names: authors list (link)
• Flory MR, Moser MJ, Monnat RJ, Davis TN (2000). "Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5919–23. PMID 10823944.CS1 maint: Multiple names: authors list (link)
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Q, Hansen D, Killilea A; et al. (2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1". J. Cell. Sci. 114 (Pt 4): 797–809. PMID 11171385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi M, Yamagiwa A, Nishimura T; et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMID 12221128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flory MR, Davis TN (2004). "The centrosomal proteins pericentrin and kendrin are encoded by alternatively spliced products of one gene". Genomics. 82 (3): 401–5. PMID 12906865.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang F, Re F, Sebastian S; et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Mol. Biol. Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMID 14767062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyoshi K, Asanuma M, Miyazaki I; et al. (2004). "DISC1 localizes to the centrosome by binding to kendrin". Biochem. Biophys. Res. Commun. 317 (4): 1195–9. doi:10.1016/j.bbrc.2004.03.163. PMID 15094396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jurczyk A, Gromley A, Redick S; et al. (2004). "Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43. doi:10.1083/jcb.200405023. PMID 15337773.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Golubkov VS, Chekanov AV, Doxsey SJ, Strongin AY (2006). "Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis". J. Biol. Chem. 280 (51): 42237–41. doi:10.1074/jbc.M510139200. PMID 16251193.CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)