PDCD6IP

Programmed cell death 6 interacting protein
File:PBB Protein PDCD6IP image.jpg PDB rendering based on 2oev.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2oev​, 2oew​, 2oex​, 2ojq​
Identifiers
Symbols	PDCD6IP ; AIP1; Alix; DRIP4; HP95; MGC17003
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22614
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDCD6IP 217746 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Programmed cell death 6 interacting protein, also known as PDCD6IP, is a human gene.

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.

Further reading

• Wood JD, Yuan J, Margolis RL; et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vito P, Pellegrini L, Guiet C, D'Adamio L (1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J. Biol. Chem. 274 (3): 1533–40. PMID 9880530.CS1 maint: Multiple names: authors list (link)
• Missotten M, Nichols A, Rieger K, Sadoul R (1999). "Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein". Cell Death Differ. 6 (2): 124–9. doi:10.1038/sj.cdd.4400456. PMID 10200558.CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu Y, Pan S, Che S; et al. (2002). "Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells". Differentiation. 67 (4–5): 139–53. PMID 11683497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satoh H, Shibata H, Nakano Y; et al. (2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochem. Biophys. Res. Commun. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID 11883939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chatellard-Causse C, Blot B, Cristina N; et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu Y, Pan S, Luo W; et al. (2002). "Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells". Oncogene. 21 (44): 6801–8. doi:10.1038/sj.onc.1205849. PMID 12360406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vincent O, Rainbow L, Tilburn J; et al. (2003). "YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix". Mol. Cell. Biol. 23 (5): 1647–55. PMID 12588984.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidt MH, Chen B, Randazzo LM, Bogler O (2004). "SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion". J. Cell. Sci. 116 (Pt 14): 2845–55. doi:10.1242/jcs.00522. PMID 12771190.CS1 maint: Multiple names: authors list (link)
• Katoh K, Shibata H, Suzuki H; et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. PMID 12927788.CS1 maint: Multiple names: authors list (link)
• Strack B, Calistri A, Craig S; et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. PMID 14505569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• von Schwedler UK, Stuchell M, Müller B; et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. PMID 14505570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin-Serrano J, Yarovoy A, Perez-Caballero D; et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMID 14519844.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMID 14583093.CS1 maint: Multiple names: authors list (link)
• Katoh K, Shibata H, Hatta K, Maki M (2004). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch. Biochem. Biophys. 421 (1): 159–65. PMID 14678797.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuo H, Chevallier J, Mayran N; et al. (2004). "Role of LBPA and Alix in multivesicular liposome formation and endosome organization". Science. 303 (5657): 531–4. doi:10.1126/science.1092425. PMID 14739459.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)