PDE4A

Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
File:PBB Protein PDE4A image.jpg PDB rendering based on 1loi.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1loi​
Identifiers
Symbols	PDE4A ; DPDE2; PDE4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4520
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDE4A 204735 at tn.png
File:PBB GE PDE4A 211447 s at tn.png
File:PBB GE PDE4A 211591 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila), also known as PDE4A, is a human gene.

Further reading

• Houslay MD, Schafer P, Zhang KY (2006). "Keynote review: phosphodiesterase-4 as a therapeutic target". Drug Discov. Today. 10 (22): 1503–19. doi:10.1016/S1359-6446(05)03622-6. PMID 16257373.CS1 maint: Multiple names: authors list (link)
• Zhang KY, Ibrahim PN, Gillette S, Bollag G (2006). "Phosphodiesterase-4 as a potential drug target". Expert Opin. Ther. Targets. 9 (6): 1283–305. doi:10.1517/14728222.9.6.1283. PMID 16300476.CS1 maint: Multiple names: authors list (link)
• Livi GP, Kmetz P, McHale MM; et al. (1990). "Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase". Mol. Cell. Biol. 10 (6): 2678–86. PMID 2160582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Horton YM, Sullivan M, Houslay MD (1995). "Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]". Biochem. J. 308 ( Pt 2): 683–91. PMID 7772058.CS1 maint: Multiple names: authors list (link)
• Sullivan M, Egerton M, Shakur Y; et al. (1995). "Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)". Cell. Signal. 6 (7): 793–812. PMID 7888306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. PMID 8009369.CS1 maint: Multiple names: authors list (link)
• Bolger G, Michaeli T, Martins T; et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. PMID 8413254.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huston E, Pooley L, Julien P; et al. (1997). "The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram". J. Biol. Chem. 271 (49): 31334–44. PMID 8940140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sullivan M, Rena G, Begg F; et al. (1998). "Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2". Biochem. J. 333 ( Pt 3): 693–703. PMID 9677330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McPhee I, Yarwood SJ, Scotland G; et al. (1999). "Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition". J. Biol. Chem. 274 (17): 11796–810. PMID 10206997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.CS1 maint: Multiple names: authors list (link)
• Secchiero P, Zella D, Curreli S; et al. (2001). "Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14620–5. doi:10.1073/pnas.011512398. PMID 11114167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zauli G, Milani D, Mirandola P; et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rena G, Begg F, Ross A; et al. (2001). "Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10". Mol. Pharmacol. 59 (5): 996–1011. PMID 11306681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lario PI, Bobechko B, Bateman K; et al. (2001). "Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells". Arch. Biochem. Biophys. 394 (1): 54–60. doi:10.1006/abbi.2001.2513. PMID 11566027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moon E, Lee R, Near R; et al. (2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clin. Cancer Res. 8 (2): 589–95. PMID 11839681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laliberté F, Liu S, Gorseth E; et al. (2002). "In vitro PKA phosphorylation-mediated human PDE4A4 activation". FEBS Lett. 512 (1–3): 205–8. PMID 11852080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baillie GS, Huston E, Scotland G; et al. (2002). "TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid". J. Biol. Chem. 277 (31): 28298–309. doi:10.1074/jbc.M108353200. PMID 11994273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pryzwansky KB, Madden VJ (2004). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils". Cell Tissue Res. 312 (3): 301–11. doi:10.1007/s00441-003-0728-y. PMID 12764607.