PEA15

Phosphoprotein enriched in astrocytes 15
File:PBB Protein PEA15 image.jpg PDB rendering based on 1n3k.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1n3k​
Identifiers
Symbols	PEA15 ; MAT1; PED; HMAT1; HUMMAT1H; MAT1H; PEA-15
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7884
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PEA15 200788 s at tn.png
File:PBB GE PEA15 200787 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphoprotein enriched in astrocytes 15, also known as PEA15, is a human gene.

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[supplied by OMIM]

Further reading

• Araujo H, Danziger N, Cordier J; et al. (1993). "Characterization of PEA-15, a major substrate for protein kinase C in astrocytes". J. Biol. Chem. 268 (8): 5911–20. PMID 8449955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Estellés A, Yokoyama M, Nothias F; et al. (1996). "The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human". J. Biol. Chem. 271 (25): 14800–6. PMID 8662970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hwang S, Kuo WL, Cochran JF; et al. (1997). "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers". Genomics. 42 (3): 540–2. PMID 9205133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Condorelli G, Vigliotta G, Iavarone C; et al. (1998). "PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus". EMBO J. 17 (14): 3858–66. doi:10.1093/emboj/17.14.3858. PMID 9670003.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kubes M, Cordier J, Glowinski J; et al. (1998). "Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro". J. Neurochem. 71 (3): 1307–14. PMID 9721757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Condorelli G, Vigliotta G, Cafieri A; et al. (1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis". Oncogene. 18 (31): 4409–15. doi:10.1038/sj.onc.1202831. PMID 10442631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitsberg D, Formstecher E, Fauquet M; et al. (1999). "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. Neurosci. 19 (19): 8244–51. PMID 10493725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolford JK, Bogardus C, Ossowski V, Prochazka M (2000). "Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians". Gene. 241 (1): 143–8. PMID 10607908.CS1 maint: Multiple names: authors list (link)
• Zhang Y, Redina O, Altshuller YM; et al. (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Formstecher E, Ramos JW, Fauquet M; et al. (2001). "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell. 1 (2): 239–50. PMID 11702783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Condorelli G, Trencia A, Vigliotta G; et al. (2002). "Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function". J. Biol. Chem. 277 (13): 11013–8. doi:10.1074/jbc.M110934200. PMID 11790785.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao C, Yang BF, Asadi N; et al. (2002). "Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells". J. Biol. Chem. 277 (28): 25020–5. doi:10.1074/jbc.M202946200. PMID 11976344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vaidyanathan H, Ramos JW (2003). "RSK2 activity is regulated by its interaction with PEA-15". J. Biol. Chem. 278 (34): 32367–72. doi:10.1074/jbc.M303988200. PMID 12796492.
• Trencia A, Perfetti A, Cassese A; et al. (2003). "Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action". Mol. Cell. Biol. 23 (13): 4511–21. PMID 12808093.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trencia A, Fiory F, Maitan MA; et al. (2004). "Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15". J. Biol. Chem. 279 (45): 46566–72. doi:10.1074/jbc.M406317200. PMID 15328349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gaumont-Leclerc MF, Mukhopadhyay UK, Goumard S, Ferbeyre G (2004). "PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence". J. Biol. Chem. 279 (45): 46802–9. doi:10.1074/jbc.M403893200. PMID 15331596.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW (2006). "Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD". Biochem. J. 390 (Pt 3): 729–35. doi:10.1042/BJ20050378. PMID 15916534.CS1 maint: Multiple names: authors list (link)