PGRMC1

Progesterone receptor membrane component 1
Identifiers
Symbols	PGRMC1 ; HPR6.6; MPR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48457
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PGRMC1 201121 s at tn.png
File:PBB GE PGRMC1 201120 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Progesterone receptor membrane component 1, also known as PGRMC1, is a human gene.

Progesterone binding protein is a putative steroid membrane receptor. The protein is expressed predominantly in the liver and kidney.

Further reading

• Gerdes D, Wehling M, Leube B, Falkenstein E (1998). "Cloning and tissue expression of two putative steroid membrane receptors". Biol. Chem. 379 (7): 907–11. PMID 9705155.CS1 maint: Multiple names: authors list (link)
• Bernauer S, Wehling M, Gerdes D, Falkenstein E (2002). "The human membrane progesterone receptor gene: genomic structure and promoter analysis". DNA Seq. 12 (1): 13–25. PMID 11697142.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shin BK, Wang H, Yim AM; et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hand RA, Craven RJ (2004). "Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells". J. Cell. Biochem. 90 (3): 534–47. doi:10.1002/jcb.10648. PMID 14523988.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lösel R, Breiter S, Seyfert M; et al. (2005). "Classic and non-classic progesterone receptors are both expressed in human spermatozoa". Horm. Metab. Res. 37 (1): 10–4. doi:10.1055/s-2005-861023. PMID 15702432.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suchanek M, Radzikowska A, Thiele C (2005). "Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells". Nat. Methods. 2 (4): 261–7. doi:10.1038/nmeth752. PMID 15782218.CS1 maint: Multiple names: authors list (link)
• Crudden G, Loesel R, Craven RJ (2005). "Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors". Tumour Biol. 26 (3): 142–6. doi:10.1159/000086485. PMID 15970648.CS1 maint: Multiple names: authors list (link)
• Crudden G, Chitti RE, Craven RJ (2006). "Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs". J. Pharmacol. Exp. Ther. 316 (1): 448–55. doi:10.1124/jpet.105.094631. PMID 16234411.CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hughes AL, Powell DW, Bard M; et al. (2007). "Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes". Cell Metab. 5 (2): 143–9. doi:10.1016/j.cmet.2006.12.009. PMID 17276356.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)