PIAS1

Protein inhibitor of activated STAT, 1
File:PBB Protein PIAS1 image.jpg PDB rendering based on 1v66.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1v66​
Identifiers
Symbols	PIAS1 ; GBP; DDXBP1; GU/RH-II; MGC141878; MGC141879; ZMIZ3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22953
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIAS1 217864 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein inhibitor of activated STAT, 1, also known as PIAS1, is a human gene.

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Further reading

• Valdez BC, Henning D, Perlaky L; et al. (1997). "Cloning and characterization of Gu/RH-II binding protein". Biochem. Biophys. Res. Commun. 234 (2): 335–40. doi:10.1006/bbrc.1997.6642. PMID 9177271.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu B, Liao J, Rao X; et al. (1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10626–31. PMID 9724754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tan J, Hall SH, Hamil KG; et al. (2000). "Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis". Mol. Endocrinol. 14 (1): 14–26. PMID 10628744.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liao J, Fu Y, Shuai K (2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5267–72. PMID 10805787.CS1 maint: Multiple names: authors list (link)
• Kotaja N, Aittomäki S, Silvennoinen O; et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. 14 (12): 1986–2000. PMID 11117529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gross M, Liu B, Tan J; et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells". Oncogene. 20 (29): 3880–7. doi:10.1038/sj.onc.1204489. PMID 11439351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu B, Shuai K (2001). "Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation". J. Biol. Chem. 276 (39): 36624–31. doi:10.1074/jbc.M101085200. PMID 11451946.
• Kahyo T, Nishida T, Yasuda H (2001). "Involvement of PIAS1 in the sumoylation of tumor suppressor p53". Mol. Cell. 8 (3): 713–8. PMID 11583632.CS1 maint: Multiple names: authors list (link)
• Weiskirchen R, Moser M, Weiskirchen S; et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. PMID 11672422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Megidish T, Xu JH, Xu CW (2002). "Activation of p53 by protein inhibitor of activated Stat1 (PIAS1)". J. Biol. Chem. 277 (10): 8255–9. doi:10.1074/jbc.C200001200. PMID 11788578.CS1 maint: Multiple names: authors list (link)
• Schmidt D, Müller S (2002). "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872–7. doi:10.1073/pnas.052559499. PMID 11867732.
• Tan JA, Hall SH, Hamil KG; et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators". J. Biol. Chem. 277 (19): 16993–7001. doi:10.1074/jbc.M109217200. PMID 11877418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishida T, Yasuda H (2003). "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription". J. Biol. Chem. 277 (44): 41311–7. doi:10.1074/jbc.M206741200. PMID 12177000.
• Rui HL, Fan E, Zhou HM; et al. (2003). "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling". J. Biol. Chem. 277 (45): 42981–6. doi:10.1074/jbc.M208099200. PMID 12223491.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sapetschnig A, Rischitor G, Braun H; et al. (2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. 21 (19): 5206–15. PMID 12356736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyauchi Y, Yogosawa S, Honda R; et al. (2003). "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes". J. Biol. Chem. 277 (51): 50131–6. doi:10.1074/jbc.M208319200. PMID 12393906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ungureanu D, Vanhatupa S, Kotaja N; et al. (2004). "PIAS proteins promote SUMO-1 conjugation to STAT1". Blood. 102 (9): 3311–3. doi:10.1182/blood-2002-12-3816. PMID 12855578.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kadaré G, Toutant M, Formstecher E; et al. (2004). "PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation". J. Biol. Chem. 278 (48): 47434–40. doi:10.1074/jbc.M308562200. PMID 14500712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tallec LP, Kirsh O, Lecomte MC; et al. (2004). "Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification". Mol. Endocrinol. 17 (12): 2529–42. doi:10.1210/me.2003-0299. PMID 14500761.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)