PIM1

Pim-1 oncogene
File:PBB Protein PIM1 image.jpg PDB rendering based on 1xqz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xqz​, 1xr1​, 1xws​, 1yhs​, 1yi3​, 1yi4​, 1ywv​, 1yxs​, 1yxt​, 1yxu​, 1yxv​, 1yxx​, 2bik​, 2bil​, 2bzh​, 2bzi​, 2bzj​, 2bzk​, 2c3i​, 2j2i​, 2o3p​, 2o63​, 2o64​, 2o65​, 2obj​, 2oi4​
Identifiers
Symbols	PIM1 ; PIM
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11214
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIM1 209193 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pim-1 oncogene, also known as PIM1, is a human gene.

The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer.[supplied by OMIM]

Further reading

• Ragoussis J, Senger G, Mockridge I; et al. (1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. PMID 1427894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saris CJ, Domen J, Berns A (1991). "The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG". EMBO J. 10 (3): 655–64. PMID 1825810.CS1 maint: Multiple names: authors list (link)
• Reeves R, Spies GA, Kiefer M; et al. (1990). "Primary structure of the putative human oncogene, pim-1". Gene. 90 (2): 303–7. PMID 2205533.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amson R, Sigaux F, Przedborski S; et al. (1989). "The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8857–61. PMID 2682662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Telerman A, Amson R, Zakut-Houri R, Givol D (1988). "Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity". Mol. Cell. Biol. 8 (4): 1498–503. PMID 2837645.CS1 maint: Multiple names: authors list (link)
• Domen J, Von Lindern M, Hermans A; et al. (1988). "Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein". Oncogene Res. 1 (1): 103–12. PMID 3329709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meeker TC, Nagarajan L, ar-Rushdi A, Croce CM (1988). "Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases". J. Cell. Biochem. 35 (2): 105–12. doi:10.1002/jcb.240350204. PMID 3429489.CS1 maint: Multiple names: authors list (link)
• Zakut-Houri R, Hazum S, Givol D, Telerman A (1987). "The cDNA sequence and gene analysis of the human pim oncogene". Gene. 54 (1): 105–11. PMID 3475233.CS1 maint: Multiple names: authors list (link)
• Leverson JD, Koskinen PJ, Orrico FC; et al. (1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Mol. Cell. 2 (4): 417–25. PMID 9809063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mochizuki T, Kitanaka C, Noguchi K; et al. (1999). "Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway". J. Biol. Chem. 274 (26): 18659–66. PMID 10373478.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koike N, Maita H, Taira T; et al. (2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. PMID 10664448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maita H, Harada Y, Nagakubo D; et al. (2000). "PAP-1, a novel target protein of phosphorylation by pim-1 kinase". Eur. J. Biochem. 267 (16): 5168–78. PMID 10931201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizuno K, Shirogane T, Shinohara A; et al. (2001). "Regulation of Pim-1 by Hsp90". Biochem. Biophys. Res. Commun. 281 (3): 663–9. doi:10.1006/bbrc.2001.4405. PMID 11237709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parks WT, Frank DB, Huff C; et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Z, Bhattacharya N, Meyer MK; et al. (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasqualucci L, Neumeister P, Goossens T; et al. (2001). "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas". Nature. 412 (6844): 341–6. doi:10.1038/35085588. PMID 11460166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishibashi Y, Maita H, Yano M; et al. (2001). "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus". FEBS Lett. 506 (1): 33–8. PMID 11591366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rainio EM, Sandholm J, Koskinen PJ (2002). "Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase". J. Immunol. 168 (4): 1524–7. PMID 11823475.CS1 maint: Multiple names: authors list (link)
• Nieborowska-Skorska M, Hoser G, Kossev P; et al. (2002). "Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis". Blood. 99 (12): 4531–9. PMID 12036885.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhattacharya N, Wang Z, Davitt C; et al. (2003). "Pim-1 associates with protein complexes necessary for mitosis". Chromosoma. 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. PMID 12111331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)