PIP4K2A

Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
Identifiers
Symbols	PIP5K2A ; PIP5KII-alpha; PIPK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37995
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIP5K2A 205570 at tn.png
File:PBB GE PIP5K2A 212829 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha, also known as PIP5K2A, is a human gene.

Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family.

Further reading

• Loijens JC, Boronenkov IV, Parker GJ, Anderson RA (1996). "The phosphatidylinositol 4-phosphate 5-kinase family". Adv. Enzyme Regul. 36: 115–40. PMID 8869744.CS1 maint: Multiple names: authors list (link)
• Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. PMID 14614850.
• Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/ . PMID 15046600.
• Tolias KF, Cantley LC, Carpenter CL (1995). "Rho family GTPases bind to phosphoinositide kinases". J. Biol. Chem. 270 (30): 17656–9. PMID 7629060.CS1 maint: Multiple names: authors list (link)
• Divecha N, Truong O, Hsuan JJ; et al. (1995). "The cloning and sequence of the C isoform of PtdIns4P 5-kinase". Biochem. J. 309 ( Pt 3): 715–9. PMID 7639683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boronenkov IV, Anderson RA (1995). "The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases". J. Biol. Chem. 270 (7): 2881–4. PMID 7852364.
• Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rozenvayn N, Flaumenhaft R (2003). "Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion". J. Biol. Chem. 278 (10): 8126–34. doi:10.1074/jbc.M206493200. PMID 12509423.
• Saito K, Tolias KF, Saci A; et al. (2003). "BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity". Immunity. 19 (5): 669–78. PMID 14614854.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwab SG, Knapp M, Sklar P; et al. (2006). "Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia". Mol. Psychiatry. 11 (9): 837–46. doi:10.1038/sj.mp.4001864. PMID 16801950.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bakker SC, Hoogendoorn ML, Hendriks J; et al. (2007). "The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia". Genes Brain Behav. 6 (2): 113–9. PMID 17410640.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He Z, Li Z, Shi Y; et al. (2007). "The PIP5K2A gene and schizophrenia in the Chinese population--a case-control study". Schizophrenia Research. 94 (1–3): 359–65. doi:10.1016/j.schres.2007.04.013. PMID 17555944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)