PLCB1

Phospholipase C, beta 1 (phosphoinositide-specific)
Identifiers
Symbols	PLCB1 ; PI-PLC; FLJ45792; PLC-154; PLC-I
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22876
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PLCB1 211925 s at tn.png
File:PBB GE PLCB1 213222 at tn.png
File:PBB GE PLCB1 215687 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phospholipase C, beta 1 (phosphoinositide-specific), also known as PLCB1, is a human gene.

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martelli AM, Fiume R, Faenza I; et al. (2006). "Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction". Histol. Histopathol. 20 (4): 1251–60. PMID 16136505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cocco L, Follo MY, Faenza I; et al. (2007). "Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells". Adv. Enzyme Regul. 47: 2–9. doi:10.1016/j.advenzreg.2006.12.003. PMID 17335878.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cefai D, Debre P, Kaczorek M; et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. PMID 1979339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zauli G, Previati M, Caramelli E; et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. PMID 7589147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hwang SC, Park KH, Ha MJ; et al. (1997). "Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization". J. Korean Med. Sci. 11 (4): 305–13. PMID 8878798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Snow BE, Hall RA, Krumins AM; et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. PMID 9651375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mayne M, Bratanich AC, Chen P; et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. PMID 9730685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. PMID 10501179.CS1 maint: Multiple names: authors list (link)
• Peruzzi D, Calabrese G, Faenza I; et al. (2000). "Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1)". Biochim. Biophys. Acta. 1484 (2–3): 175–82. PMID 10760467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. PMID 10843712.CS1 maint: Multiple names: authors list (link)
• Tang Y, Tang J, Chen Z; et al. (2001). "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF". J. Biol. Chem. 275 (48): 37559–64. doi:10.1074/jbc.M006635200. PMID 10980202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caricasole A, Sala C, Roncarati R; et al. (2001). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72. PMID 11118617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dowal L, Elliott J, Popov S; et al. (2001). "Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1". Biochemistry. 40 (2): 414–21. PMID 11148035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu A, Wang Y, Xu LY, Gilmour RS (2001). "Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells". J. Biol. Chem. 276 (18): 14980–6. doi:10.1074/jbc.M009144200. PMID 11278470.CS1 maint: Multiple names: authors list (link)
• Xu A, Suh PG, Marmy-Conus N; et al. (2001). "Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I.". Mol. Cell. Biol. 21 (9): 2981–90. doi:10.1128/MCB.21.9.2981-2990.2001. PMID 11287604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vitale M, Matteucci A, Manzoli L; et al. (2001). "Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells". FASEB J. 15 (10): 1789–91. PMID 11481231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.". Nat. Struct. Biol. 9 (1): 32–6. doi:10.1038/nsb731. PMID 11753430.CS1 maint: Multiple names: authors list (link)