PLCD3

Phospholipase C, delta 3
Identifiers
Symbols	PLCD3 ; MGC71172
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14858
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phospholipase C, delta 3, also known as PLCD3, is a human gene.

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.

Further reading

• Cefai D, Debre P, Kaczorek M; et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. PMID 1979339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zauli G, Previati M, Caramelli E; et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. PMID 7589147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ghosh S, Pawelczyk T, Lowenstein JM (1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr. Purif. 9 (2): 262–78. PMID 9056492.CS1 maint: Multiple names: authors list (link)
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.CS1 maint: Multiple names: authors list (link)
• Pawełczyk T, Matecki A (1998). "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3". Acta Biochim. Pol. 44 (2): 221–9. PMID 9360711.
• Mayne M, Bratanich AC, Chen P; et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. PMID 9730685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pawelczyk T, Matecki A (1998). "Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium". Eur. J. Biochem. 257 (1): 169–77. PMID 9799116.
• Pawelczyk T, Matecki A (1999). "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes". Eur. J. Biochem. 262 (2): 291–8. PMID 10336610.
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. PMID 10501179.CS1 maint: Multiple names: authors list (link)
• Kim H, Suh PG, Ryu SH, Park SH (2000). "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 209–10. PMID 10702670.CS1 maint: Multiple names: authors list (link)
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. PMID 10843712.CS1 maint: Multiple names: authors list (link)
• Lin FG, Cheng HF, Lee IF; et al. (2001). "Downregulation of phospholipase C delta3 by cAMP and calcium". Biochem. Biophys. Res. Commun. 286 (2): 274–80. doi:10.1006/bbrc.2001.5371. PMID 11500033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ananthanarayanan B, Das S, Rhee SG; et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". J. Biol. Chem. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. PMID 11853319.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. PMID 12482669.CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)