PLD2

Phospholipase D2
Identifiers
Symbols	PLD2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55672
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PLD2 209643 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phospholipase D2, also known as PLD2, is a human gene.

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM]

Further reading

• Sundaram M, Cook HW, Byers DM (2004). "The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular components". Biochem. Cell Biol. 82 (1): 191–200. doi:10.1139/o03-087. PMID 15052337.CS1 maint: Multiple names: authors list (link)
• McDermott M, Wakelam MJ, Morris AJ (2004). "Phospholipase D.". Biochem. Cell Biol. 82 (1): 225–53. doi:10.1139/o03-079. PMID 15052340.CS1 maint: Multiple names: authors list (link)
• Colley WC, Sung TC, Roll R; et al. (1997). "Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization". Curr. Biol. 7 (3): 191–201. PMID 9395408.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lopez I, Arnold RS, Lambeth JD (1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". J. Biol. Chem. 273 (21): 12846–52. PMID 9582313.CS1 maint: Multiple names: authors list (link)
• Steed PM, Clark KL, Boyar WC, Lasala DJ (1998). "Characterization of human PLD2 and the analysis of PLD isoform splice variants". FASEB J. 12 (13): 1309–17. PMID 9761774.CS1 maint: Multiple names: authors list (link)
• Slaaby R, Jensen T, Hansen HS; et al. (1999). "PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation". J. Biol. Chem. 273 (50): 33722–7. PMID 9837959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park SH, Ryu SH, Suh PG, Kim H (1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 225. PMID 9858823.CS1 maint: Multiple names: authors list (link)
• Czarny M, Fiucci G, Lavie Y; et al. (2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains". FEBS Lett. 467 (2–3): 326–32. PMID 10675563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee C, Kim SR, Chung JK; et al. (2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. 275 (25): 18751–8. doi:10.1074/jbc.M001695200. PMID 10764771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park JB, Kim JH, Kim Y; et al. (2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. 275 (28): 21295–301. doi:10.1074/jbc.M002463200. PMID 10801846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Redina O, Altshuller YM; et al. (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morash SC, Byers DM, Cook HW (2000). "Activation of phospholipase D by PKC and GTPgammaS in human neuroblastoma cells overexpressing MARCKS". Biochim. Biophys. Acta. 1487 (2–3): 177–89. PMID 11018470.CS1 maint: Multiple names: authors list (link)
• Divecha N, Roefs M, Halstead JR; et al. (2000). "Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMID 11032811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Slaaby R, Du G, Altshuller YM; et al. (2001). "Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade". Biochem. J. 351 Pt 3: 613–9. PMID 11042115.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Lee S, Park JB, Kim JH; et al. (2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. 276 (30): 28252–60. doi:10.1074/jbc.M008521200. PMID 11373276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sarkar S, Miwa N, Kominami H; et al. (2001). "Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator". Biochem. J. 359 (Pt 3): 599–604. PMID 11672434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denmat-Ouisse LA, Phebidias C, Honkavaara P; et al. (2002). "Regulation of constitutive protein transit by phospholipase D in HT29-cl19A cells". J. Biol. Chem. 276 (52): 48840–6. doi:10.1074/jbc.M104276200. PMID 11687572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee S, Kim JH, Lee CS; et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction". J. Biol. Chem. 277 (8): 6542–9. doi:10.1074/jbc.M108047200. PMID 11741937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Han JM, Kim JH, Lee BD; et al. (2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol. Chem. 277 (10): 8290–7. doi:10.1074/jbc.M108343200. PMID 11744693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)