PODXL

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Podocalyxin-like
Identifiers
Symbols PODXL ; Gp200; MGC138240; PCLP
External IDs Template:OMIM5 Template:MGI HomoloGene: 3937
RNA expression pattern
File:PBB GE PODXL 201578 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Podocalyxin-like, also known as PODXL, is a human gene.[1]

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PODXL podocalyxin-like".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Kershaw DB, Beck SG, Wharram BL; et al. (1997). "Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin". J. Biol. Chem. 272 (25): 15708–14. PMID 9188463.
  • Kershaw DB, Wiggins JE, Wharram BL, Wiggins RC (1997). "Assignment of the human podocalyxin-like protein (PODXL) gene to 7q32-q33". Genomics. 45 (1): 239–40. doi:10.1006/geno.1997.4934. PMID 9339384.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Sassetti C, Tangemann K, Singer MS; et al. (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34". J. Exp. Med. 187 (12): 1965–75. PMID 9625756.
  • Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
  • Takeda T, McQuistan T, Orlando RA, Farquhar MG (2001). "Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton". J. Clin. Invest. 108 (2): 289–301. PMID 11457882.
  • Li Y, Li J, Straight SW, Kershaw DB (2002). "PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2". Am. J. Physiol. Renal Physiol. 282 (6): F1129–39. doi:10.1152/ajprenal.00131.2001. PMID 11997330.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Schopperle WM, Kershaw DB, DeWolf WC (2003). "Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin". Biochem. Biophys. Res. Commun. 300 (2): 285–90. PMID 12504081.
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
  • Koop K, Eikmans M, Baelde HJ; et al. (2004). "Expression of podocyte-associated molecules in acquired human kidney diseases". J. Am. Soc. Nephrol. 14 (8): 2063–71. PMID 12874460.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Economou CG, Kitsiou PV, Tzinia AK; et al. (2005). "Enhanced podocalyxin expression alters the structure of podocyte basal surface". J. Cell. Sci. 117 (Pt 15): 3281–94. doi:10.1242/jcs.01163. PMID 15226400.
  • Somasiri A, Nielsen JS, Makretsov N; et al. (2004). "Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression". Cancer Res. 64 (15): 5068–73. doi:10.1158/0008-5472.CAN-04-0240. PMID 15289306.
  • Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
  • Meder D, Shevchenko A, Simons K, Füllekrug J (2005). "Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells". J. Cell Biol. 168 (2): 303–13. doi:10.1083/jcb.200407072. PMID 15642748.
  • Casey G, Neville PJ, Liu X; et al. (2006). "Podocalyxin variants and risk of prostate cancer and tumor aggressiveness". Hum. Mol. Genet. 15 (5): 735–41. doi:10.1093/hmg/ddi487. PMID 16434482.
  • Butta N, Larrucea S, Alonso S; et al. (2006). "Role of transcription factor Sp1 and CpG methylation on the regulation of the human podocalyxin gene promoter". BMC Mol. Biol. 7: 17. doi:10.1186/1471-2199-7-17. PMID 16684343.

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