POLG2

Polymerase (DNA directed), gamma 2, accessory subunit
File:PBB Protein POLG2 image.jpg PDB rendering based on 2g4c.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2g4c​
Identifiers
Symbols	POLG2 ; POLB; HP55; MTPOLB; PEOA4; POLGB
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5221
Gene ontology Molecular function Template:GNF GOTemplate:GNF GOTemplate:GNF GOTemplate:GNF GOTemplate:GNF GOTemplate:GNF GOTemplate:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE POLG2 205811 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Polymerase (DNA directed), gamma 2, accessory subunit, also known as POLG2, is a human gene.

Further reading

• Michiels S, Danoy P, Dessen P; et al. (2007). "Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers". Carcinogenesis. 28 (8): 1731–9. doi:10.1093/carcin/bgm111. PMID 17494052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang H, Shiffman ML, Cheung RC; et al. (2006). "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.". Gastroenterology. 130 (6): 1679–87. doi:10.1053/j.gastro.2006.02.032. PMID 16697732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Longley MJ, Clark S, Yu Wai Man C; et al. (2006). "Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia". Am. J. Hum. Genet. 78 (6): 1026–34. doi:10.1086/504303. PMID 16685652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yakubovskaya E, Chen Z, Carrodeguas JA; et al. (2006). "Functional human mitochondrial DNA polymerase gamma forms a heterotrimer". J. Biol. Chem. 281 (1): 374–82. doi:10.1074/jbc.M509730200. PMID 16263719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carrodeguas JA, Pinz KG, Bogenhagen DF (2003). "DNA binding properties of human pol gammaB". J. Biol. Chem. 277 (51): 50008–14. doi:10.1074/jbc.M207030200. PMID 12379656.CS1 maint: Multiple names: authors list (link)
• Johnson AA, Tsai Y, Graves SW, Johnson KA (2000). "Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization". Biochemistry. 39 (7): 1702–8. PMID 10677218.CS1 maint: Multiple names: authors list (link)
• Carrodeguas JA, Bogenhagen DF (2000). "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase". Nucleic Acids Res. 28 (5): 1237–44. PMID 10666468.
• Lim SE, Longley MJ, Copeland WC (2000). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. PMID 10608893.CS1 maint: Multiple names: authors list (link)
• Wang Y, Farr CL, Kaguni LS (1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J. Biol. Chem. 272 (21): 13640–6. PMID 9153213.CS1 maint: Multiple names: authors list (link)