PON2

Paraoxonase 2
Identifiers
Symbols	PON2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 385
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PON2 201876 at tn.png
File:PBB GE PON2 210830 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Paraoxonase 2, also known as PON2, is a human gene.

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Mackness B, Durrington PN, Mackness MI (2003). "The paraoxonase gene family and coronary heart disease". Curr. Opin. Lipidol. 13 (4): 357–62. PMID 12151850.CS1 maint: Multiple names: authors list (link)
• Getz GS, Reardon CA (2005). "Paraoxonase, a cardioprotective enzyme: continuing issues". Curr. Opin. Lipidol. 15 (3): 261–7. PMID 15166781.
• Ng CJ, Shih DM, Hama SY; et al. (2005). "The paraoxonase gene family and atherosclerosis". Free Radic. Biol. Med. 38 (2): 153–63. doi:10.1016/j.freeradbiomed.2004.09.035. PMID 15607899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. PMID 8661009.CS1 maint: Multiple names: authors list (link)
• Hegele RA, Connelly PW, Scherer SW; et al. (1997). "Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus". J. Clin. Endocrinol. Metab. 82 (10): 3373–7. PMID 9329371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanghera DK, Aston CE, Saha N, Kamboh MI (1998). "DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease". Am. J. Hum. Genet. 62 (1): 36–44. PMID 9443862.CS1 maint: Multiple names: authors list (link)
• Mochizuki H, Scherer SW, Xi T; et al. (1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene. 213 (1–2): 149–57. PMID 9714608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Ng CJ, Wadleigh DJ, Gangopadhyay A; et al. (2002). "Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein". J. Biol. Chem. 276 (48): 44444–9. doi:10.1074/jbc.M105660200. PMID 11579088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hong SH, Song J, Min WK, Kim JQ (2002). "Genetic variations of the paraoxonase gene in patients with coronary artery disease". Clin. Biochem. 34 (6): 475–81. PMID 11676977.CS1 maint: Multiple names: authors list (link)
• Obineche EN, Frossard PM, Bokhari AM (2002). "An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs". Hypertens. Res. 24 (6): 635–9. PMID 11768721.CS1 maint: Multiple names: authors list (link)
• Janka Z, Juhász A, Rimanóczy A A; et al. (2002). "Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias". Mol. Psychiatry. 7 (1): 110–2. doi:10.1038/sj/mp/4000916. PMID 11803456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kao Y, Donaghue KC, Chan A; et al. (2002). "Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes". Diabet. Med. 19 (3): 212–5. PMID 11918623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Q, Reis SE, Kammerer CM; et al. (2003). "Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study". Am. J. Hum. Genet. 72 (1): 13–22. PMID 12454802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada Y, Ando F, Niino N; et al. (2003). "Association of polymorphisms of paraoxonase 1 and 2 genes, alone or in combination, with bone mineral density in community-dwelling Japanese". J. Hum. Genet. 48 (9): 469–75. doi:10.1007/s10038-003-0063-x. PMID 12955589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi J, Zhang S, Tang M; et al. (2004). "Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese". Brain Res. Mol. Brain Res. 120 (2): 201–4. PMID 14741412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)