PPP1R14A
Protein phosphatase 1, regulatory (inhibitor) subunit 14A | |||||||
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Identifiers | |||||||
Symbols | PPP1R14A ; CPI-17; PPP1INL | ||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 12267 | ||||||
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Orthologs | |||||||
Template:GNF Ortholog box | |||||||
Species | Human | Mouse | |||||
Entrez | n/a | n/a | |||||
Ensembl | n/a | n/a | |||||
UniProt | n/a | n/a | |||||
RefSeq (mRNA) | n/a | n/a | |||||
RefSeq (protein) | n/a | n/a | |||||
Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a |
Protein phosphatase 1, regulatory (inhibitor) subunit 14A, also known as PPP1R14A, is a human gene.[1]
PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase (see MIM 603768). Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration.[supplied by OMIM][1]
References
Further reading
- Eto M, Ohmori T, Suzuki M; et al. (1996). "A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization". J. Biochem. 118 (6): 1104–7. PMID 8720121.
- Eto M, Senba S, Morita F, Yazawa M (1997). "Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle". FEBS Lett. 410 (2–3): 356–60. PMID 9237662.
- Koyama M, Ito M, Feng J; et al. (2000). "Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase". FEBS Lett. 475 (3): 197–200. PMID 10869555.
- Hamaguchi T, Ito M, Feng J; et al. (2000). "Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N.". Biochem. Biophys. Res. Commun. 274 (3): 825–30. doi:10.1006/bbrc.2000.3225. PMID 10924361.
- Yamawaki K, Ito M, Machida H; et al. (2001). "Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase". Biochem. Biophys. Res. Commun. 285 (4): 1040–5. doi:10.1006/bbrc.2001.5290. PMID 11467857.
- Li Z, Yu L, Zhang Y; et al. (2002). "Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2". Mol. Biol. Rep. 28 (2): 91–101. PMID 11931393.
- Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. 517 (1–3): 167–71. PMID 12062430.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Liu QR, Zhang PW, Lin Z; et al. (2004). "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA". Biochem. J. 377 (Pt 1): 171–81. doi:10.1042/BJ20030128. PMID 12974676.
- Zemlickova E, Johannes FJ, Aitken A, Dubois T (2004). "Association of CPI-17 with protein kinase C and casein kinase I.". Biochem. Biophys. Res. Commun. 316 (1): 39–47. doi:10.1016/j.bbrc.2004.02.014. PMID 15003508.
- Kolosova IA, Ma SF, Adyshev DM; et al. (2004). "Role of CPI-17 in the regulation of endothelial cytoskeleton". Am. J. Physiol. Lung Cell Mol. Physiol. 287 (5): L970–80. doi:10.1152/ajplung.00398.2003. PMID 15234908.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Jin H, Sperka T, Herrlich P, Morrison H (2006). "Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase". Nature. 442 (7102): 576–9. doi:10.1038/nature04856. PMID 16885985.
- Morin C, Sirois M, Echave V; et al. (2007). "Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi". Am. J. Respir. Cell Mol. Biol. 36 (5): 633–41. doi:10.1165/rcmb.2006-0281OC. PMID 17237191.
- Lartey J, Smith M, Pawade J; et al. (2007). "Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor". Biol. Reprod. 76 (6): 971–82. doi:10.1095/biolreprod.106.058982. PMID 17301291.
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