PPP2R2B
| Protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PPP2R2B ; MGC24888; PP2A-PR55B; PR2AB-BETA; PR2AB55-BETA; PR2APR55-BETA; PR52B; PR55-BETA; SCA12 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55833 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PPP2R2B 213849 s at tn.png | |||||||||||
| File:PBB GE PPP2R2B 205643 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform, also known as PPP2R2B, is a human gene.
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.[1]
References
Further reading
- Millward TA, Zolnierowicz S, Hemmings BA (1999). "Regulation of protein kinase cascades by protein phosphatase 2A". Trends Biochem. Sci. 24 (5): 186–91. PMID 10322434.
- Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. PMID 15638722.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Mayer RE, Hendrix P, Cron P; et al. (1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. PMID 1849734.
- Schalling M, Hudson TJ, Buetow KH, Housman DE (1993). "Direct detection of novel expanded trinucleotide repeats in the human genome". Nat. Genet. 4 (2): 135–9. doi:10.1038/ng0693-135. PMID 8348150.
- Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
- Strack S, Zaucha JA, Ebner FF; et al. (1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". J. Comp. Neurol. 392 (4): 515–27. PMID 9514514.
- Holmes SE, O'Hearn EE, McInnis MG; et al. (1999). "Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12". Nat. Genet. 23 (4): 391–2. doi:10.1038/70493. PMID 10581021.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.
- Fujigasaki H, Verma IC, Camuzat A; et al. (2001). "SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family". Ann. Neurol. 49 (1): 117–21. PMID 11198281.
- Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Guo CY, Brautigan DL, Larner JM (2002). "ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation". J. Biol. Chem. 277 (7): 4839–44. doi:10.1074/jbc.M110092200. PMID 11723136.
- Bennin DA, Don AS, Brake T; et al. (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.
- Okamoto K, Li H, Jensen MR; et al. (2002). "Cyclin G recruits PP2A to dephosphorylate Mdm2". Mol. Cell. 9 (4): 761–71. PMID 11983168.
- Marmorstein LY, McLaughlin PJ, Stanton JB; et al. (2002). "Bestrophin interacts physically and functionally with protein phosphatase 2A". J. Biol. Chem. 277 (34): 30591–7. doi:10.1074/jbc.M204269200. PMID 12058047.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMID 12110603.
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