PPP2R5D

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Protein phosphatase 2, regulatory subunit B', delta isoform
File:PBB Protein PPP2R5D image.jpg
PDB rendering based on 2jak.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols PPP2R5D ; B56D; MGC2134; MGC8949
External IDs Template:OMIM5 Template:MGI HomoloGene: 37661
RNA expression pattern
File:PBB GE PPP2R5D 202513 s at tn.png
File:PBB GE PPP2R5D 211159 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Protein phosphatase 2, regulatory subunit B', delta isoform, also known as PPP2R5D, is a human gene.[1]

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform".

Further reading

  • Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
  • Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
  • Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
  • McCright B, Virshup DM (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem. 270 (44): 26123–8. PMID 7592815.
  • Tanabe O, Nagase T, Murakami T; et al. (1996). "Molecular cloning of a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A". FEBS Lett. 379 (1): 107–11. PMID 8566219.
  • McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. PMID 8703017.
  • McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. PMID 8812429.
  • Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.
  • Tanabe O, Gomez GA, Nishito Y; et al. (1997). "Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A". FEBS Lett. 408 (1): 52–6. PMID 9180267.
  • Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
  • Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.
  • Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
  • Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMID 12110603.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Firulli BA, Howard MJ, McDaid JR; et al. (2004). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. PMID 14636580.
  • Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

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