PPP2R5E
| Protein phosphatase 2, regulatory subunit B', epsilon isoform | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PPP2R5E ; | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55962 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PPP2R5E 203338 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Protein phosphatase 2, regulatory subunit B', epsilon isoform, also known as PPP2R5E, is a human gene.[1]
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.[1]
References
Further reading
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- McCright B, Virshup DM (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem. 270 (44): 26123–8. PMID 7592815.
- Zolnierowicz S, Van Hoof C, Andjelković N; et al. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". Biochem. J. 317 ( Pt 1): 187–94. PMID 8694763.
- McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. PMID 8703017.
- McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. PMID 8812429.
- Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.
- Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMID 12110603.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
- Dozier C, Bonyadi M, Baricault L; et al. (2005). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit". Biol. Cell. 96 (7): 509–17. doi:10.1016/j.biolcel.2004.04.010. PMID 15380617.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ammosova T, Washington K, Debebe Z; et al. (2006). "Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription". Retrovirology. 2: 47. doi:10.1186/1742-4690-2-47. PMID 16048649.
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